TY - JOUR
T1 - Conducting a two-stage preference trial
T2 - Utility and challenges
AU - Sidani, Souraya
AU - Fox, Mary
AU - Epstein, Dana
N1 - Funding Information:
Partially supported by the Canadian Institutes of Health Research–Canada Research Chair Program , the Canadian Institutes of Health Research , and the National Institutes of Health ( NR05075 ).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015
Y1 - 2015
N2 - Treatment preferences reflect individuals' choice of therapy and influence their adherence to treatment and achievement of outcomes. The two-stage partially randomized clinical or preference trial (two-stage PRCT) is an appropriate design for examining the contribution of treatment preferences. It involves a two-stage process for assigning participants to treatments, which is useful to dismantle the effects of the treatments from those of treatment preferences. In this paper, we explain the role of treatment preferences in intervention evaluation research, describe the protocol for implementing the two-stage PRCT, and discuss issues in its application. The issues are encountered in the selection of treatments, assignment of participants and assessment of treatment preferences. Lastly, we propose ways to address the issues.
AB - Treatment preferences reflect individuals' choice of therapy and influence their adherence to treatment and achievement of outcomes. The two-stage partially randomized clinical or preference trial (two-stage PRCT) is an appropriate design for examining the contribution of treatment preferences. It involves a two-stage process for assigning participants to treatments, which is useful to dismantle the effects of the treatments from those of treatment preferences. In this paper, we explain the role of treatment preferences in intervention evaluation research, describe the protocol for implementing the two-stage PRCT, and discuss issues in its application. The issues are encountered in the selection of treatments, assignment of participants and assessment of treatment preferences. Lastly, we propose ways to address the issues.
KW - Assessment of preferences
KW - Assignment to treatment
KW - Design
KW - Intervention research
KW - Methodology
KW - Preference trials
KW - Treatment selection
KW - Two-stage partially randomized trial
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U2 - 10.1016/j.ijnurstu.2015.02.006
DO - 10.1016/j.ijnurstu.2015.02.006
M3 - Comment/debate
C2 - 25736207
AN - SCOPUS:84933279662
SN - 0020-7489
VL - 52
SP - 1017
EP - 1024
JO - International Journal of Nursing Studies
JF - International Journal of Nursing Studies
IS - 5
ER -