Concurrent testing of droplet-based microfluidic systems for multiplexed biomedical assays

Fei Su, Sule Ozev, Krishnendu Chakrabarty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

50 Scopus citations

Abstract

We present a concurrent testing methodology for detecting catastrophic faults in droplet-based microfluidic systems and investigate the related problems of test planning and resource optimization. We apply this methodology to a droplet-based microfluidic array that was fabricated and used to perform multiplexed glucose and lactate assays. The test approach interleaves test application with the biomedical assays and prevents resource conflicts. We show that an integer linear programming model can be used to minimize testing time for a given hardware overhead due to droplet dispensing sources and capacitive sensing circuitry. The proposed approach is therefore directed at ensuring high reliability and availability of bio-MEMS and lab-on-a-chip systems, as they are increasingly deployed for safety-critical applications.

Original languageEnglish (US)
Title of host publicationProceedings - International Test Conference
Pages883-892
Number of pages10
StatePublished - 2004
Externally publishedYes
EventProceedings - International Test Conference 2004 - Charlotte, NC, United States
Duration: Oct 26 2004Oct 28 2004

Other

OtherProceedings - International Test Conference 2004
CountryUnited States
CityCharlotte, NC
Period10/26/0410/28/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Su, F., Ozev, S., & Chakrabarty, K. (2004). Concurrent testing of droplet-based microfluidic systems for multiplexed biomedical assays. In Proceedings - International Test Conference (pp. 883-892)