Comparison of the atavistic model of cancer to somatic mutation theory: Phylostratigraphic analyses support the atavistic model

Charles H. Lineweaver, Paul C.W. Davies

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

We review the atavistic model of cancer1 and compare it with the leading model: Somatic Mutation Theory (SMT). We identify their differences and describe specific predictions of the atavistic model that make it more easily tested than SMT. The increasingly dense phylogenetic tree of all life on Earth has permitted a range of phylostratigraphic analyses which support the atavistic model.

Original languageEnglish (US)
Title of host publicationPhysics Of Cancer, The
Subtitle of host publicationResearch Advances
PublisherWorld Scientific Publishing Co.
Pages243-261
Number of pages19
ISBN (Electronic)9789811223495
DOIs
StatePublished - Jan 1 2020

Keywords

  • Atavistic model
  • cancer
  • Hallmarks
  • Somatic mutation theory

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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