Comparison of the atavistic model of cancer to somatic mutation theory: Phylostratigraphic analyses support the atavistic model

Charles H. Lineweaver; Paul C.W. Davies

doi:10.1142/9789811223495_0012

Comparison of the atavistic model of cancer to somatic mutation theory: Phylostratigraphic analyses support the atavistic model

Charles H. Lineweaver, Paul C.W. Davies

Physics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

Abstract

We review the atavistic model of cancer¹ and compare it with the leading model: Somatic Mutation Theory (SMT). We identify their differences and describe specific predictions of the atavistic model that make it more easily tested than SMT. The increasingly dense phylogenetic tree of all life on Earth has permitted a range of phylostratigraphic analyses which support the atavistic model.

Original language	English (US)
Title of host publication	Physics Of Cancer, The
Subtitle of host publication	Research Advances
Publisher	World Scientific Publishing Co.
Pages	243-261
Number of pages	19
ISBN (Electronic)	9789811223495
DOIs	https://doi.org/10.1142/9789811223495_0012
State	Published - Jan 1 2020

Keywords

Atavistic model
Hallmarks
Somatic mutation theory
cancer

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1142/9789811223495_0012

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abstract = "We review the atavistic model of cancer1 and compare it with the leading model: Somatic Mutation Theory (SMT). We identify their differences and describe specific predictions of the atavistic model that make it more easily tested than SMT. The increasingly dense phylogenetic tree of all life on Earth has permitted a range of phylostratigraphic analyses which support the atavistic model.",

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Comparison of the atavistic model of cancer to somatic mutation theory: Phylostratigraphic analyses support the atavistic model

Abstract

Keywords

ASJC Scopus subject areas

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