TY - JOUR
T1 - Comparative pathogenesis of haemorrhagic enteritis virus (HEV) infection in turkeys and chickens
AU - Rautenschlein, S.
AU - Suresh, M.
AU - Neumann, U.
AU - Sharma, J. M.
PY - 1998
Y1 - 1998
N2 - The pathogenesis of haemorrhagic enteritis virus (HEV) infection in chickens 3-4 days post-infection was compared with that in turkeys. As expected, infected turkeys showed HEV-specific lesions that included enlargement and mottling of the spleen, as well as haemorrhagic enteritis. In infected chickens, only splenomegaly was observed. The number of HEV-infected cells in the spleen was significantly (P < 0.05) higher in the turkey than in the chicken. In both species, the immunohistochemical labelling of B-cell surface determinants was diminished and the splenic B-cell areas were undetectable after HEV infection. Infection with HEV resulted in an increase in nitric oxide production by macrophages in chickens but not in turkeys.
AB - The pathogenesis of haemorrhagic enteritis virus (HEV) infection in chickens 3-4 days post-infection was compared with that in turkeys. As expected, infected turkeys showed HEV-specific lesions that included enlargement and mottling of the spleen, as well as haemorrhagic enteritis. In infected chickens, only splenomegaly was observed. The number of HEV-infected cells in the spleen was significantly (P < 0.05) higher in the turkey than in the chicken. In both species, the immunohistochemical labelling of B-cell surface determinants was diminished and the splenic B-cell areas were undetectable after HEV infection. Infection with HEV resulted in an increase in nitric oxide production by macrophages in chickens but not in turkeys.
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U2 - 10.1016/S0021-9975(98)80048-0
DO - 10.1016/S0021-9975(98)80048-0
M3 - Article
C2 - 9807727
AN - SCOPUS:0031761604
SN - 0021-9975
VL - 119
SP - 251
EP - 261
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
IS - 3
ER -