Comparative Genomics in Eukaryotes

Alan Filipski, Sudhir Kumar

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

This chapter outlines the development and current status of comparative eukaryotic genomics, from the earliest studies of basic chromosome structure to the sequencing of entire genomes. In the process, a review is provided for the structure, organization, and composition of the primary eukaryotic genomes that have been sequenced thus far. Although the word "genome," meaning the total hereditary material of an organism, was coined in 1920, the general concept of genome arose before 4th century, when Aristotle implicated blood as the heredity substance. The notions of "blood relations" and characteristics being "in one's blood" persist; it is now known that the blood of mammals actually contains very little genetic material because their erythrocytes contain neither nuclei nor mitochondria. Although its roots can be traced back to the earliest chromosomal work, comparative genomics involving complete genome sequencing is a science still in its infancy. Fast-growing and full of potential, its maturation is expected to influence an increasingly broad array of biological disciplines. Already, widespread implications can be envisioned for evolutionary biology, medicine, and agriculture; in some cases, these have already become reality. The large-scale comparison, and perhaps even manipulation, of genomes is a complex undertaking involving numerous empirical, analytical, and ethical issues. Both important challenges and exciting discoveries lie ahead for genome biology.

Original languageEnglish (US)
Title of host publicationThe Evolution of the Genome
PublisherElsevier Inc.
Pages521-583
Number of pages63
ISBN (Print)9780123014634
DOIs
StatePublished - 2005

Fingerprint

Genomics
Eukaryota
eukaryotic cells
Genome
genomics
genome
blood
Chromosome Structures
Biological Sciences
Heredity
infancy
Agriculture
Ethics
Mammals
inheritance (genetics)
Mitochondria
medicine
mitochondria
erythrocytes
Erythrocytes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Filipski, A., & Kumar, S. (2005). Comparative Genomics in Eukaryotes. In The Evolution of the Genome (pp. 521-583). Elsevier Inc.. https://doi.org/10.1016/B978-012301463-4/50011-5

Comparative Genomics in Eukaryotes. / Filipski, Alan; Kumar, Sudhir.

The Evolution of the Genome. Elsevier Inc., 2005. p. 521-583.

Research output: Chapter in Book/Report/Conference proceedingChapter

Filipski, A & Kumar, S 2005, Comparative Genomics in Eukaryotes. in The Evolution of the Genome. Elsevier Inc., pp. 521-583. https://doi.org/10.1016/B978-012301463-4/50011-5
Filipski A, Kumar S. Comparative Genomics in Eukaryotes. In The Evolution of the Genome. Elsevier Inc. 2005. p. 521-583 https://doi.org/10.1016/B978-012301463-4/50011-5
Filipski, Alan ; Kumar, Sudhir. / Comparative Genomics in Eukaryotes. The Evolution of the Genome. Elsevier Inc., 2005. pp. 521-583
@inbook{9920bb48c08b48a9a53f95c51c773cfe,
title = "Comparative Genomics in Eukaryotes",
abstract = "This chapter outlines the development and current status of comparative eukaryotic genomics, from the earliest studies of basic chromosome structure to the sequencing of entire genomes. In the process, a review is provided for the structure, organization, and composition of the primary eukaryotic genomes that have been sequenced thus far. Although the word {"}genome,{"} meaning the total hereditary material of an organism, was coined in 1920, the general concept of genome arose before 4th century, when Aristotle implicated blood as the heredity substance. The notions of {"}blood relations{"} and characteristics being {"}in one's blood{"} persist; it is now known that the blood of mammals actually contains very little genetic material because their erythrocytes contain neither nuclei nor mitochondria. Although its roots can be traced back to the earliest chromosomal work, comparative genomics involving complete genome sequencing is a science still in its infancy. Fast-growing and full of potential, its maturation is expected to influence an increasingly broad array of biological disciplines. Already, widespread implications can be envisioned for evolutionary biology, medicine, and agriculture; in some cases, these have already become reality. The large-scale comparison, and perhaps even manipulation, of genomes is a complex undertaking involving numerous empirical, analytical, and ethical issues. Both important challenges and exciting discoveries lie ahead for genome biology.",
author = "Alan Filipski and Sudhir Kumar",
year = "2005",
doi = "10.1016/B978-012301463-4/50011-5",
language = "English (US)",
isbn = "9780123014634",
pages = "521--583",
booktitle = "The Evolution of the Genome",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Comparative Genomics in Eukaryotes

AU - Filipski, Alan

AU - Kumar, Sudhir

PY - 2005

Y1 - 2005

N2 - This chapter outlines the development and current status of comparative eukaryotic genomics, from the earliest studies of basic chromosome structure to the sequencing of entire genomes. In the process, a review is provided for the structure, organization, and composition of the primary eukaryotic genomes that have been sequenced thus far. Although the word "genome," meaning the total hereditary material of an organism, was coined in 1920, the general concept of genome arose before 4th century, when Aristotle implicated blood as the heredity substance. The notions of "blood relations" and characteristics being "in one's blood" persist; it is now known that the blood of mammals actually contains very little genetic material because their erythrocytes contain neither nuclei nor mitochondria. Although its roots can be traced back to the earliest chromosomal work, comparative genomics involving complete genome sequencing is a science still in its infancy. Fast-growing and full of potential, its maturation is expected to influence an increasingly broad array of biological disciplines. Already, widespread implications can be envisioned for evolutionary biology, medicine, and agriculture; in some cases, these have already become reality. The large-scale comparison, and perhaps even manipulation, of genomes is a complex undertaking involving numerous empirical, analytical, and ethical issues. Both important challenges and exciting discoveries lie ahead for genome biology.

AB - This chapter outlines the development and current status of comparative eukaryotic genomics, from the earliest studies of basic chromosome structure to the sequencing of entire genomes. In the process, a review is provided for the structure, organization, and composition of the primary eukaryotic genomes that have been sequenced thus far. Although the word "genome," meaning the total hereditary material of an organism, was coined in 1920, the general concept of genome arose before 4th century, when Aristotle implicated blood as the heredity substance. The notions of "blood relations" and characteristics being "in one's blood" persist; it is now known that the blood of mammals actually contains very little genetic material because their erythrocytes contain neither nuclei nor mitochondria. Although its roots can be traced back to the earliest chromosomal work, comparative genomics involving complete genome sequencing is a science still in its infancy. Fast-growing and full of potential, its maturation is expected to influence an increasingly broad array of biological disciplines. Already, widespread implications can be envisioned for evolutionary biology, medicine, and agriculture; in some cases, these have already become reality. The large-scale comparison, and perhaps even manipulation, of genomes is a complex undertaking involving numerous empirical, analytical, and ethical issues. Both important challenges and exciting discoveries lie ahead for genome biology.

UR - http://www.scopus.com/inward/record.url?scp=33646573747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646573747&partnerID=8YFLogxK

U2 - 10.1016/B978-012301463-4/50011-5

DO - 10.1016/B978-012301463-4/50011-5

M3 - Chapter

SN - 9780123014634

SP - 521

EP - 583

BT - The Evolution of the Genome

PB - Elsevier Inc.

ER -