TY - JOUR
T1 - Coffee with High but Not Low Caffeine Content Augments Fluid and Electrolyte Excretion at Rest
AU - Seal, Adam D.
AU - Bardis, Costas N.
AU - Gavrieli, Anna
AU - Grigorakis, Petros
AU - Adams, J. D.
AU - Arnaoutis, Giannis
AU - Yannakoulia, Mary
AU - Kavouras, Stavros A.
N1 - Funding Information:
The study was funded by the Graduate Program of the Department of Nutrition and Dietetics at Harokopio University.
Publisher Copyright:
© Copyright © 2017 Seal, Bardis, Gavrieli, Grigorakis, Adams, Arnaoutis, Yannakoulia and Kavouras.
PY - 2017/8/18
Y1 - 2017/8/18
N2 - Background: Low levels of caffeine ingestion do not induce dehydration at rest, while it is not clear if larger doses do have an acute diuretic effect. The aim of the present investigation was to examine the acute effect of low and high levels of caffeine, via coffee, on fluid balance in habitual coffee drinkers (at least one per day) at rest. Methods: Ten healthy adults (eight males and two females; age: 27 ± 5 years, weight: 89.5 ± 14.8 kg, height: 1.75 ± 0.08 m, and body mass index: 29.1 ± 4.4 kg m−2) ingested 200 mL of water (W), coffee with low caffeine (3 mg kg−1, LCAF), or coffee with high caffeine (6 mg kg−1, HCAF) on three respective separate occasions. All sessions were performed at 09:00 in the morning in a counterbalanced, crossover manner, at least 5 days apart. Subjects remained in the laboratory while urine samples were collected every 60 min for 3 h post ingestion. Results: Absolute caffeine consumption was 269 ± 45 and 537 ± 89 mg for the LCAF and HCAF, respectively. Coffee ingestion at the HCAF trial induced greater diuresis during the 3-h period (613 ± 101 mL, P < 0.05), when compared to W (356 ± 53 mL) and LCAF (316 ± 38 mL). In addition, cumulative urinary osmotic excretion was significantly greater in the HCAF (425 ± 92 mmol, P < 0.05), as compared to the W (249 ± 36 mmol) and LCAF (177 ± 16 mmol) trials. Conclusion: The data indicate that caffeine intake of 6 mg kg−1 in the form of coffee can induce an acute diuretic effect, while 3 mg kg−1 do not disturb fluid balance in healthy casual coffee drinking adults at rest.
AB - Background: Low levels of caffeine ingestion do not induce dehydration at rest, while it is not clear if larger doses do have an acute diuretic effect. The aim of the present investigation was to examine the acute effect of low and high levels of caffeine, via coffee, on fluid balance in habitual coffee drinkers (at least one per day) at rest. Methods: Ten healthy adults (eight males and two females; age: 27 ± 5 years, weight: 89.5 ± 14.8 kg, height: 1.75 ± 0.08 m, and body mass index: 29.1 ± 4.4 kg m−2) ingested 200 mL of water (W), coffee with low caffeine (3 mg kg−1, LCAF), or coffee with high caffeine (6 mg kg−1, HCAF) on three respective separate occasions. All sessions were performed at 09:00 in the morning in a counterbalanced, crossover manner, at least 5 days apart. Subjects remained in the laboratory while urine samples were collected every 60 min for 3 h post ingestion. Results: Absolute caffeine consumption was 269 ± 45 and 537 ± 89 mg for the LCAF and HCAF, respectively. Coffee ingestion at the HCAF trial induced greater diuresis during the 3-h period (613 ± 101 mL, P < 0.05), when compared to W (356 ± 53 mL) and LCAF (316 ± 38 mL). In addition, cumulative urinary osmotic excretion was significantly greater in the HCAF (425 ± 92 mmol, P < 0.05), as compared to the W (249 ± 36 mmol) and LCAF (177 ± 16 mmol) trials. Conclusion: The data indicate that caffeine intake of 6 mg kg−1 in the form of coffee can induce an acute diuretic effect, while 3 mg kg−1 do not disturb fluid balance in healthy casual coffee drinking adults at rest.
KW - caffeine
KW - coffee
KW - dehydration
KW - electrolytes
KW - fluid balance
KW - hydration
KW - hypohydration
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U2 - 10.3389/fnut.2017.00040
DO - 10.3389/fnut.2017.00040
M3 - Article
AN - SCOPUS:85050472802
SN - 2296-861X
VL - 4
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
M1 - 40
ER -