Clonal evolution in cancer

Mel Greaves, Carlo C. Maley

Research output: Contribution to journalReview articlepeer-review

1672 Scopus citations

Abstract

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

Original languageEnglish (US)
Pages (from-to)306-313
Number of pages8
JournalNature
Volume481
Issue number7381
DOIs
StatePublished - Jan 19 2012
Externally publishedYes

ASJC Scopus subject areas

  • General

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