Clonal evolution in cancer

Mel Greaves; Carlo C. Maley

doi:10.1038/nature10762

Clonal evolution in cancer

Mel Greaves, Carlo C. Maley

Research output: Contribution to journal › Review article › peer-review

2206 Scopus citations

Abstract

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

Original language	English (US)
Pages (from-to)	306-313
Number of pages	8
Journal	Nature
Volume	481
Issue number	7381
DOIs	https://doi.org/10.1038/nature10762
State	Published - Jan 19 2012
Externally published	Yes

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title = "Clonal evolution in cancer",

abstract = "Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.",

author = "Mel Greaves and Maley, {Carlo C.}",

note = "Funding Information: Acknowledgements The research of M.G. is supported by Leukaemia & Lymphoma Research UK and The Kay Kendall Leukaemia Fund. The research of C.M. is supported by Research Scholar Grant #117209-RSG-09-163-01-CNE from the American Cancer Society and NIH grants P01 CA91955, U54 CA143803, R01 CA149566 and R01 CA140657. The authors thank C.Cooper and J.Clark for the use of the image in Fig. 4.",

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AU - Maley, Carlo C.

N1 - Funding Information: Acknowledgements The research of M.G. is supported by Leukaemia & Lymphoma Research UK and The Kay Kendall Leukaemia Fund. The research of C.M. is supported by Research Scholar Grant #117209-RSG-09-163-01-CNE from the American Cancer Society and NIH grants P01 CA91955, U54 CA143803, R01 CA149566 and R01 CA140657. The authors thank C.Cooper and J.Clark for the use of the image in Fig. 4.

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N2 - Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

AB - Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

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Clonal evolution in cancer

Abstract

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