Cellular dehydration acutely degrades mood mainly in women: A counterbalanced, crossover trial

Hyungyu Suh; Harris R. Lieberman; Lisa T. Jansen; Abigail T. Colburn; J. D. Adams; Adam D. Seal; Cory L. Butts; Tracie M. Kirkland; Olle Melander; Tiphaine Vanhaecke; Alberto Dolci; Guillaume Lemetais; Erica T. Perrier; Stavros A. Kavouras

doi:10.1017/S0007114520003475

Cellular dehydration acutely degrades mood mainly in women: A counterbalanced, crossover trial

Hyungyu Suh, Harris R. Lieberman, Lisa T. Jansen, Abigail T. Colburn, J. D. Adams, Adam D. Seal, Cory L. Butts, Tracie M. Kirkland, Olle Melander, Tiphaine Vanhaecke, Alberto Dolci, Guillaume Lemetais, Erica T. Perrier, Stavros A. Kavouras

Health Solutions, College of (CHS)

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (sd 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (sd 3), post 305 (sd 4) mmol/kg; P < 0·05) but remained unchanged in ISO (pre 285 (sd 3), post 288 (sd 3) mmol/kg; P > 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO (P < 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 (sd 0·9) to 16·6 (sd 1·7) in HYPER (P < 0·01), but not in ISO (P > 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females (P < 0·01) but not in males (P > 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 (sd 2·0), 14·1 (sd 1·4) pmol/l; P < 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.

Original language	English (US)
Pages (from-to)	1092-1100
Number of pages	9
Journal	British Journal of Nutrition
Volume	125
Issue number	10
DOIs	https://doi.org/10.1017/S0007114520003475
State	Published - May 28 2021

Keywords

Copeptin
Osmotic stimulation
Thirst
Underhydation
Vasopressin

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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10.1017/S0007114520003475

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Suh, H., Lieberman, H. R., Jansen, L. T., Colburn, A. T., Adams, J. D., Seal, A. D., Butts, C. L., Kirkland, T. M., Melander, O., Vanhaecke, T., Dolci, A., Lemetais, G., Perrier, E. T., & Kavouras, S. A. (2021). Cellular dehydration acutely degrades mood mainly in women: A counterbalanced, crossover trial. British Journal of Nutrition, 125(10), 1092-1100. https://doi.org/10.1017/S0007114520003475

Suh, H, Lieberman, HR, Jansen, LT, Colburn, AT, Adams, JD, Seal, AD, Butts, CL, Kirkland, TM, Melander, O, Vanhaecke, T, Dolci, A, Lemetais, G, Perrier, ET & Kavouras, SA 2021, 'Cellular dehydration acutely degrades mood mainly in women: A counterbalanced, crossover trial', British Journal of Nutrition, vol. 125, no. 10, pp. 1092-1100. https://doi.org/10.1017/S0007114520003475

@article{44a715a9e2614c6ebddc31334ae15f96,

title = "Cellular dehydration acutely degrades mood mainly in women: A counterbalanced, crossover trial",

abstract = "It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (sd 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (sd 3), post 305 (sd 4) mmol/kg; P < 0·05) but remained unchanged in ISO (pre 285 (sd 3), post 288 (sd 3) mmol/kg; P > 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO (P < 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 (sd 0·9) to 16·6 (sd 1·7) in HYPER (P < 0·01), but not in ISO (P > 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females (P < 0·01) but not in males (P > 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 (sd 2·0), 14·1 (sd 1·4) pmol/l; P < 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.",

keywords = "Copeptin, Osmotic stimulation, Thirst, Underhydation, Vasopressin",

author = "Hyungyu Suh and Lieberman, {Harris R.} and Jansen, {Lisa T.} and Colburn, {Abigail T.} and Adams, {J. D.} and Seal, {Adam D.} and Butts, {Cory L.} and Kirkland, {Tracie M.} and Olle Melander and Tiphaine Vanhaecke and Alberto Dolci and Guillaume Lemetais and Perrier, {Erica T.} and Kavouras, {Stavros A.}",

note = "Funding Information: The study was funded by a grant from Danone Research, France (no. EAU-8644-GD). Publisher Copyright: {\textcopyright} The Author(s), 2020.",

year = "2021",

month = may,

day = "28",

doi = "10.1017/S0007114520003475",

language = "English (US)",

volume = "125",

pages = "1092--1100",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "10",

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T1 - Cellular dehydration acutely degrades mood mainly in women

T2 - A counterbalanced, crossover trial

AU - Suh, Hyungyu

AU - Lieberman, Harris R.

AU - Jansen, Lisa T.

AU - Colburn, Abigail T.

AU - Adams, J. D.

AU - Seal, Adam D.

AU - Butts, Cory L.

AU - Kirkland, Tracie M.

AU - Melander, Olle

AU - Vanhaecke, Tiphaine

AU - Dolci, Alberto

AU - Lemetais, Guillaume

AU - Perrier, Erica T.

AU - Kavouras, Stavros A.

PY - 2021/5/28

Y1 - 2021/5/28

N2 - It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (sd 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (sd 3), post 305 (sd 4) mmol/kg; P < 0·05) but remained unchanged in ISO (pre 285 (sd 3), post 288 (sd 3) mmol/kg; P > 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO (P < 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 (sd 0·9) to 16·6 (sd 1·7) in HYPER (P < 0·01), but not in ISO (P > 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females (P < 0·01) but not in males (P > 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 (sd 2·0), 14·1 (sd 1·4) pmol/l; P < 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.

AB - It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (sd 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (sd 3), post 305 (sd 4) mmol/kg; P < 0·05) but remained unchanged in ISO (pre 285 (sd 3), post 288 (sd 3) mmol/kg; P > 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO (P < 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 (sd 0·9) to 16·6 (sd 1·7) in HYPER (P < 0·01), but not in ISO (P > 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females (P < 0·01) but not in males (P > 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 (sd 2·0), 14·1 (sd 1·4) pmol/l; P < 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.

KW - Copeptin

KW - Osmotic stimulation

KW - Thirst

KW - Underhydation

KW - Vasopressin

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JO - British Journal of Nutrition

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Cellular dehydration acutely degrades mood mainly in women: A counterbalanced, crossover trial

Abstract

Keywords

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