Cell-mediated cytotoxic response to cells bearing marek’s disease tumor-associated surface antigen in chickens infected with marek’s disease virus

J. M. Sharma, B. D. Coulson

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

In a microcytotoxicity test in which51Cr-labeled cells of a Marek’s disease (MD) lymphoblastoid line (MSB-1 line) were used, cell-mediated cytotoxicity of spleen cell suspensions prepared from chickens inoculated with MD virus was demonstrated. This cytotoxic response, presumably directed against MD tumor-associated surface antigen, was detectable briefly after virus infection and paralleled the appearance of early lymphoproliferative lesions characteristic of MD.

Original languageEnglish (US)
Pages (from-to)1647-1651
Number of pages5
JournalJournal of the National Cancer Institute
Volume58
Issue number6
DOIs
StatePublished - Jun 1977

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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