Carvedilol update III: Rationale for use in congestive heart failure

G. Z. Feuerstein, G. Poste, R. R. Ruffolo

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

In February of 1995, several multicenter, double-blind, placebo-controlled clinical trials of the novel, multiple action cardiovascular drug, carvedilol, were terminated prematurely for ethical reasons due to the remarkable reduction in mortality observed in patients receiving carvedilol plus conventional therapy (i.e., angiotensin converting enzyme inhibitors, diuretics and digitalis) compared to patients receiving placebo plus conventional therapy. The dramatic reduction in mortality produced by carvedilol occurred across all studies and was observed in patients with mild, moderate and severe heart failure. The results of these dramatic clinical trials with carvedilol will be presented later this year.

Original languageEnglish (US)
Pages (from-to)307-326
Number of pages20
JournalDrugs of Today
Volume31
Issue number5
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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