Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance

Yueqing Gu, Vikram Kodibagkar, Mengna Xia, Anca Constantinescu, Ralph P. Mason, Hanli Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of this study is to evaluate the feasibility of Near Infrared Spectroscopy (NIRS) as an in vivo monitoring tool for rat breast tumor oxygenation and vascular blood volume by comparison with the established modalities, magnetic resonance imaging/spectroscopy (MRI/MRS). The changes in oxygenated hemoglobin concentration and total hemoglobin concentration (Δ[HbO 2], Δ[Hb] total) with respect to hyperoxic gas interventions were monitored by NIRS. Changes in deoxygenated hemoglobin, a blood oxygenation level dependent (BOLD) contrast, and blood volume on breast tumors were monitored by BOLD MRI and 9F MRS of PFOB, respectively. Results showed strong consistency among the two pairs: Δ[HbO 2] versus BOLD signal, Δ[Hb] total versus tumor blood volume. These consistent results demonstrated the ability of NIRS as a valid in-vivo real time monitoring tool for studying the dynamic responses of Δ[HbO 2] and Δ[Hb] total to therapeutic interventions applied to rat breast tumors. Furthermore, the results suggested that NIRS and MRS are complimentary with each other in terms of temporal and spatial resolutions.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsB. Chance, M. Chen, A.E.T. Chiou, Q. Luo
Pages918-925
Number of pages8
Volume5630 II
DOIs
StatePublished - 2005
Externally publishedYes
EventOptics in Health Care and Biomedical Optics: Diagnostics and Treatment II - Beijing, China
Duration: Nov 8 2004Nov 12 2004

Other

OtherOptics in Health Care and Biomedical Optics: Diagnostics and Treatment II
CountryChina
CityBeijing
Period11/8/0411/12/04

Keywords

  • Breast tumor
  • Carbogen intervention
  • MRI and MRS
  • NIRS
  • Tumor blood volume
  • Tumor oxygenation

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Gu, Y., Kodibagkar, V., Xia, M., Constantinescu, A., Mason, R. P., & Liu, H. (2005). Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance. In B. Chance, M. Chen, A. E. T. Chiou, & Q. Luo (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5630 II, pp. 918-925). [181] https://doi.org/10.1117/12.591939