Bioprinting technologies for disease modeling

Adnan Memic, Ali Navaei, Bahram Mirani, Julio Alvin Vacacela Cordova, Musab Aldhahri, Alireza Dolatshahi-Pirouz, Mohsen Akbari, Mehdi Nikkhah

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

There is a great need for the development of biomimetic human tissue models that allow elucidation of the pathophysiological conditions involved in disease initiation and progression. Conventional two-dimensional (2D) in vitro assays and animal models have been unable to fully recapitulate the critical characteristics of human physiology. Alternatively, three-dimensional (3D) tissue models are often developed in a low-throughput manner and lack crucial native-like architecture. The recent emergence of bioprinting technologies has enabled creating 3D tissue models that address the critical challenges of conventional in vitro assays through the development of custom bioinks and patient derived cells coupled with well-defined arrangements of biomaterials. Here, we provide an overview on the technological aspects of 3D bioprinting technique and discuss how the development of bioprinted tissue models have propelled our understanding of diseases’ characteristics (i.e. initiation and progression). The future perspectives on the use of bioprinted 3D tissue models for drug discovery application are also highlighted.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalBiotechnology Letters
DOIs
StateAccepted/In press - May 26 2017

Fingerprint

Bioprinting
Technology
Tissue
Assays
Biomimetics
Human Development
Biocompatible Materials
Drug Discovery
Physiology
Disease Progression
Biomaterials
Animal Models
Animals
Throughput

Keywords

  • 3D bioprinting
  • Disease microenvironment
  • Disease modeling
  • In vitro tissue models

ASJC Scopus subject areas

  • Biotechnology

Cite this

Memic, A., Navaei, A., Mirani, B., Cordova, J. A. V., Aldhahri, M., Dolatshahi-Pirouz, A., ... Nikkhah, M. (Accepted/In press). Bioprinting technologies for disease modeling. Biotechnology Letters, 1-12. https://doi.org/10.1007/s10529-017-2360-z

Bioprinting technologies for disease modeling. / Memic, Adnan; Navaei, Ali; Mirani, Bahram; Cordova, Julio Alvin Vacacela; Aldhahri, Musab; Dolatshahi-Pirouz, Alireza; Akbari, Mohsen; Nikkhah, Mehdi.

In: Biotechnology Letters, 26.05.2017, p. 1-12.

Research output: Contribution to journalArticle

Memic, A, Navaei, A, Mirani, B, Cordova, JAV, Aldhahri, M, Dolatshahi-Pirouz, A, Akbari, M & Nikkhah, M 2017, 'Bioprinting technologies for disease modeling', Biotechnology Letters, pp. 1-12. https://doi.org/10.1007/s10529-017-2360-z
Memic A, Navaei A, Mirani B, Cordova JAV, Aldhahri M, Dolatshahi-Pirouz A et al. Bioprinting technologies for disease modeling. Biotechnology Letters. 2017 May 26;1-12. https://doi.org/10.1007/s10529-017-2360-z
Memic, Adnan ; Navaei, Ali ; Mirani, Bahram ; Cordova, Julio Alvin Vacacela ; Aldhahri, Musab ; Dolatshahi-Pirouz, Alireza ; Akbari, Mohsen ; Nikkhah, Mehdi. / Bioprinting technologies for disease modeling. In: Biotechnology Letters. 2017 ; pp. 1-12.
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