Biologic characteristics of premalignant breast disease

Kimberly Cole, Maria Tabernero, Karen S. Anderson

Research output: Chapter in Book/Report/Conference proceedingChapter


Breast cancer is the second leading cause of cancer death in women in the United States. While mammography and breast magnetic resonance imaging (MRI) improve detection of early disease, there remains an unmet need for biomarkers for risk stratification, early detection, prediction, and disease prognosis. A number of early breast lesions, from atypical hyperplasias to carcinomas in situ, are associated with an increased risk of developing subsequent invasive breast carcinoma. The recent development of genomic, epigenomic, and proteomic tools for tissue biomarker detection, including array CGH, RNA expression microarrays, and proteomic arrays have identified a number of potential biomarkers that both identify patients at increased risk, as well as provided insights into the pathology of early breast cancer development. This chapter focuses on the detection and application of tissue and serum biomarkers for the identification and risk stratification of early breast cancer lesions.

Original languageEnglish (US)
Title of host publicationTranslational Pathology of Early Cancer
PublisherIOS Press
Number of pages16
ISBN (Print)9781614990239
StatePublished - Mar 1 2012
Externally publishedYes


  • Benign breast disease
  • Biomarkers
  • Breast cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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