Biologic characteristics of premalignant breast disease

Kimberly Cole, Maria Tabernero, Karen Anderson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Breast cancer is the second leading cause of cancer death in women in the United States. While mammography and breast magnetic resonance imaging (MRI) improve detection of early disease, there remains an unmet need for biomarkers for risk stratification, early detection, prediction, and disease prognosis. A number of early breast lesions, from atypical hyperplasias to carcinomas in situ, are associated with an increased risk of developing subsequent invasive breast carcinoma. The recent development of genomic, epigenomic, and proteomic tools for tissue biomarker detection, including array CGH, RNA expression microarrays, and proteomic arrays have identified a number of potential biomarkers that both identify patients at increased risk, as well as provided insights into the pathology of early breast cancer development. This chapter focuses on the detection and application of tissue and serum biomarkers for the identification and risk stratification of early breast cancer lesions.

Original languageEnglish (US)
Title of host publicationTranslational Pathology of Early Cancer
PublisherIOS Press
Pages177-192
Number of pages16
ISBN (Print)9781614990239
DOIs
StatePublished - Mar 2012
Externally publishedYes

Fingerprint

Breast Diseases
Biomarkers
Breast Neoplasms
Proteomics
Early Diagnosis
Breast
Tissue
Mammography
Carcinoma in Situ
Pathology
Magnetic resonance
Microarrays
Epigenomics
Hyperplasia
Cause of Death
Magnetic Resonance Imaging
RNA
Imaging techniques
Serum
Neoplasms

Keywords

  • Benign breast disease
  • Biomarkers
  • Breast cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Cole, K., Tabernero, M., & Anderson, K. (2012). Biologic characteristics of premalignant breast disease. In Translational Pathology of Early Cancer (pp. 177-192). IOS Press. https://doi.org/10.3233/978-1-61499-024-6-177

Biologic characteristics of premalignant breast disease. / Cole, Kimberly; Tabernero, Maria; Anderson, Karen.

Translational Pathology of Early Cancer. IOS Press, 2012. p. 177-192.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cole, K, Tabernero, M & Anderson, K 2012, Biologic characteristics of premalignant breast disease. in Translational Pathology of Early Cancer. IOS Press, pp. 177-192. https://doi.org/10.3233/978-1-61499-024-6-177
Cole K, Tabernero M, Anderson K. Biologic characteristics of premalignant breast disease. In Translational Pathology of Early Cancer. IOS Press. 2012. p. 177-192 https://doi.org/10.3233/978-1-61499-024-6-177
Cole, Kimberly ; Tabernero, Maria ; Anderson, Karen. / Biologic characteristics of premalignant breast disease. Translational Pathology of Early Cancer. IOS Press, 2012. pp. 177-192
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