Bioanalysis in structured microfluidic systems

Alexandra Ros, Wibke Hellmich, Jan Regtmeier, Thanh Tu Duong, Dario Anselmetti

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Microfluidic and lab-on-a-chip devices have attracted widespread interest in separation sciences and bioanalysis. Recent designs in microfluidic devices extend common separation concepts by exploiting new phenomena for molecular dynamics on a length scale of 10 μm and below, giving rise to novel manipulation tools and nonintuitive phenomena for microseparations. Here, we focus on three very recent developments for bioseparations based on tailored microfluidic systems: Single cell navigation, trapping and steering with subsequent on-chip lysis, protein separation and LIF detection (Section 3.1), then we report dielectrophoretic trapping and separation of large DNA fragments in structured microfluidic devices (Section 3.2). Finally, a paradoxial migration phenomenon based on thermal fluctuations, periodically arranged microchannels and a biased alternating current electric field is presented in Section 3.3.

Original languageEnglish (US)
Pages (from-to)2651-2658
Number of pages8
JournalElectrophoresis
Volume27
Issue number13
DOIs
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

Lab-On-A-Chip Devices
Microfluidics
Protein Array Analysis
Molecular Dynamics Simulation
Hot Temperature
Equipment and Supplies
Lab-on-a-chip
DNA
Microchannels
Molecular dynamics
Navigation
Electric fields

Keywords

  • DNA
  • Microfluidic device
  • Migration phenomena
  • Protein
  • Single cell analytics

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Ros, A., Hellmich, W., Regtmeier, J., Duong, T. T., & Anselmetti, D. (2006). Bioanalysis in structured microfluidic systems. Electrophoresis, 27(13), 2651-2658. https://doi.org/10.1002/elps.200500923

Bioanalysis in structured microfluidic systems. / Ros, Alexandra; Hellmich, Wibke; Regtmeier, Jan; Duong, Thanh Tu; Anselmetti, Dario.

In: Electrophoresis, Vol. 27, No. 13, 07.2006, p. 2651-2658.

Research output: Contribution to journalArticle

Ros, A, Hellmich, W, Regtmeier, J, Duong, TT & Anselmetti, D 2006, 'Bioanalysis in structured microfluidic systems', Electrophoresis, vol. 27, no. 13, pp. 2651-2658. https://doi.org/10.1002/elps.200500923
Ros A, Hellmich W, Regtmeier J, Duong TT, Anselmetti D. Bioanalysis in structured microfluidic systems. Electrophoresis. 2006 Jul;27(13):2651-2658. https://doi.org/10.1002/elps.200500923
Ros, Alexandra ; Hellmich, Wibke ; Regtmeier, Jan ; Duong, Thanh Tu ; Anselmetti, Dario. / Bioanalysis in structured microfluidic systems. In: Electrophoresis. 2006 ; Vol. 27, No. 13. pp. 2651-2658.
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