TY - JOUR
T1 - Behavioral response to apomorphine and its interaction with opiates in domestic pigeons
AU - Deviche, Pierre
N1 - Funding Information:
Naloxoneh ydrochloridwe asa giftf romd u Pontd eN emouras nd Co (GlenoldenP, A, USA) whereasle vorphanoal nd dextrorphan tartratew erekindly providedb y Hoffman-LaR oche(FRG). The work wasc arriedo utin collaboratiown ithDr. M. Binder( Institute of PhysiologicalC hemistry, Ruhr-Universit~Bito chum, FRG); thanksa red uet o Prof.J . D. Deliusf or improvingth eo riginaml anu-scripta nd to Mrs. A. Lohmanna nd Mr. H. Stankewitzfo r vailed help.T hea uthorw asS eniorR esearchA ssistanat tt heB elgianF und for ScientificR esearcha ndr eceiveadn A. yon Humboldfte llowship IFRG) and a NATO grant.T he researchw as supportedb y the DeutscheF orschungsgemeinschthafrto ughi ts Sonderforschungs-bereich1 14,
PY - 1985/2
Y1 - 1985/2
N2 - Domestic pigeons received peripheral injections of saline or the dopamine agonist apomorphine (AM) at doses of 0.025, 0.05, 0.1, 0.25, 0.5 or 1 mg and their behavior was studied for 30 min after these treatments. Given at a dose of 0.025 mg, AM decreased pecking, whereas doses ranging from 0.1 to 1 mg strongly stimulated this behavior. The frequency of headshaking was enhanced by the administration of each dose of AM; at the 3 higher doses, the drug also attenuated the frequency of preening. In another experiment, AM was administered 40 min after the injection of either naloxone (0.5, 1 or 4 mg), the opiate agonist levorphanol (0.25, 0.5 or 1 mg) or its dextroisomer, dextrorphan (0.25, 0.5 or 1 mg), while the birds were observed as before. No interaction between AM and either naloxone or dextrorphan was detected. By contrast, injection of each dose of levorphanol attenuated preening, and completely antagonized the stimulating effect of AM treatment on headshaking. At a dose of 1 mg, levorphanol also slightly decreased the frequency and increased the latency of occurrence of pecking. It is concluded that in pigeons, opiates modulate the behavioral response to apomorphine in a complex fashion.
AB - Domestic pigeons received peripheral injections of saline or the dopamine agonist apomorphine (AM) at doses of 0.025, 0.05, 0.1, 0.25, 0.5 or 1 mg and their behavior was studied for 30 min after these treatments. Given at a dose of 0.025 mg, AM decreased pecking, whereas doses ranging from 0.1 to 1 mg strongly stimulated this behavior. The frequency of headshaking was enhanced by the administration of each dose of AM; at the 3 higher doses, the drug also attenuated the frequency of preening. In another experiment, AM was administered 40 min after the injection of either naloxone (0.5, 1 or 4 mg), the opiate agonist levorphanol (0.25, 0.5 or 1 mg) or its dextroisomer, dextrorphan (0.25, 0.5 or 1 mg), while the birds were observed as before. No interaction between AM and either naloxone or dextrorphan was detected. By contrast, injection of each dose of levorphanol attenuated preening, and completely antagonized the stimulating effect of AM treatment on headshaking. At a dose of 1 mg, levorphanol also slightly decreased the frequency and increased the latency of occurrence of pecking. It is concluded that in pigeons, opiates modulate the behavioral response to apomorphine in a complex fashion.
KW - Apomorphine
KW - Dopamine
KW - Naloxone
KW - Opiates
KW - Pecking
KW - Pigeons
UR - http://www.scopus.com/inward/record.url?scp=0021987750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021987750&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(85)90379-X
DO - 10.1016/0091-3057(85)90379-X
M3 - Article
C2 - 2984702
AN - SCOPUS:0021987750
SN - 0091-3057
VL - 22
SP - 209
EP - 214
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2
ER -