TY - JOUR
T1 - Association of non-exercise physical activity in mid- and late-life with cognitive trajectories and the impact of APOE ε4 genotype status
T2 - the Mayo Clinic Study of Aging
AU - Krell-Roesch, Janina
AU - Syrjanen, Jeremy A.
AU - Vassilaki, Maria
AU - Barisch-Fritz, Bettina
AU - Trautwein, Sandra
AU - Boes, Klaus
AU - Woll, Alexander
AU - Kremers, Walter K.
AU - Machulda, Mary M.
AU - Mielke, Michelle M.
AU - Knopman, David S.
AU - Petersen, Ronald C.
AU - Geda, Yonas E.
N1 - Funding Information:
Support for this research was provided by National Institutes of Health grants: National Institute of Mental Health (K01 MH068351) and National Institute on Aging (R01 AG057708, U01 AG006786, K01 AG028573 and R01 AG034676). This project was also supported by the Robert Wood Johnson Foundation, the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program, the GHR Foundation, Edli Foundation (The Hague, The Netherlands) and the Arizona Alzheimer’s Consortium.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - In this study derived from the population-based Mayo Clinic Study of Aging, we investigated whether non-exercise physical activity (PA) was associated with global and domain-specific cognitive trajectories (memory, language, visuospatial skills, attention) and whether the association differed by apolipoprotein E (APOE) ε4 genotype status. We included 2061 community-dwelling individuals aged ≥ 70 years (50.5% males, 26.7% APOE ε4 carriers) who were cognitively unimpaired at baseline and on whom serial cognitive data and self-reported information on non-exercise PA were available. We specifically inquired about non-exercise PA carried out at two time points, i.e., midlife (between 50 and 65 years of age) and late-life (within 1 year prior to assessment) and three intensity levels, i.e., light (e.g., laundry), moderate (e.g., scrubbing floors) and heavy (e.g., hard manual labor). Linear mixed-effect models revealed that engaging in midlife PA of moderate or heavy intensity was associated with significantly less-pronounced decline of z-scores in all cognitive domains. Similarly, participants that engaged in late-life moderate or heavy PA had less decline in visuospatial, attention and global z-scores than non-active peers. These associations varied depending on APOE ε4 carrier status, i.e., APOE ε4 non-carriers but not APOE ε4 carriers that engaged in late-life PA had less decline in cognitive z-scores. In contrast, engaging in midlife PA, irrespective of intensity, was significantly associated with less decline in memory function only among APOE ε4 carriers.
AB - In this study derived from the population-based Mayo Clinic Study of Aging, we investigated whether non-exercise physical activity (PA) was associated with global and domain-specific cognitive trajectories (memory, language, visuospatial skills, attention) and whether the association differed by apolipoprotein E (APOE) ε4 genotype status. We included 2061 community-dwelling individuals aged ≥ 70 years (50.5% males, 26.7% APOE ε4 carriers) who were cognitively unimpaired at baseline and on whom serial cognitive data and self-reported information on non-exercise PA were available. We specifically inquired about non-exercise PA carried out at two time points, i.e., midlife (between 50 and 65 years of age) and late-life (within 1 year prior to assessment) and three intensity levels, i.e., light (e.g., laundry), moderate (e.g., scrubbing floors) and heavy (e.g., hard manual labor). Linear mixed-effect models revealed that engaging in midlife PA of moderate or heavy intensity was associated with significantly less-pronounced decline of z-scores in all cognitive domains. Similarly, participants that engaged in late-life moderate or heavy PA had less decline in visuospatial, attention and global z-scores than non-active peers. These associations varied depending on APOE ε4 carrier status, i.e., APOE ε4 non-carriers but not APOE ε4 carriers that engaged in late-life PA had less decline in cognitive z-scores. In contrast, engaging in midlife PA, irrespective of intensity, was significantly associated with less decline in memory function only among APOE ε4 carriers.
KW - APOE ε4
KW - Cognitive trajectories
KW - Non-exercise physical activity
KW - Population-based study
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UR - http://www.scopus.com/inward/citedby.url?scp=85064257401&partnerID=8YFLogxK
U2 - 10.1007/s10433-019-00513-1
DO - 10.1007/s10433-019-00513-1
M3 - Article
AN - SCOPUS:85064257401
SN - 1613-9372
VL - 16
SP - 491
EP - 502
JO - European Journal of Ageing
JF - European Journal of Ageing
IS - 4
ER -