TY - JOUR
T1 - Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults
T2 - Mayo Clinic Study of Aging
AU - Krell-Roesch, Janina
AU - Syrjanen, Jeremy A.
AU - Mielke, Michelle M.
AU - Christianson, Teresa J.
AU - Kremers, Walter K.
AU - MacHulda, Mary M.
AU - Knopman, David S.
AU - Petersen, Ronald C.
AU - Vassilaki, Maria
AU - Geda, Yonas E.
N1 - Funding Information:
This work was supported by National Institutes of Health grants: National Institute on Aging (R01 AG057708, U01 AG006786, K01 AG028573, R01AG034676), and National Institute of Mental Health (K01 MH068351). This project was also supported by F. Hoffmann-La Roche, the Robert Wood Johnson Foundation, the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program, the GHR Foundation, the Edli Foundation, and the Arizona Alzheimer’s Consortium.
Publisher Copyright:
© 2020 - IOS Press and the authors. All rights reserved.
PY - 2020
Y1 - 2020
N2 - We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged ≥50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score ≥13) and anxiety (Beck Anxiety Inventory score ≥10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.
AB - We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged ≥50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score ≥13) and anxiety (Beck Anxiety Inventory score ≥10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.
KW - Anxiety
KW - depression
KW - functional performance
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U2 - 10.3233/JAD-200764
DO - 10.3233/JAD-200764
M3 - Article
C2 - 33074231
AN - SCOPUS:85097003326
SN - 1387-2877
VL - 78
SP - 911
EP - 917
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 3
ER -