Antineoplastic agents. Part 395. Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.

George Pettit, Jun-Ping Xu, Diane E. Gingrich, Michael D. Williams, Dennis L. Doubek, Jean Chapuis, Jean M. Schmidt

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge Agelas sp. led to isolation of a trace (7.42 x 10-6% yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 μg m-1 to ovary OVCAR-3 GI50 2.8 μg ml-1) designated agelagalastatin 6; it is the first example of a natural product containing a digalactofuranosyl unit.

Original languageEnglish (US)
Pages (from-to)915-916
Number of pages2
JournalChemical Communications
Issue number10
DOIs
StatePublished - May 21 1999

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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