Antineoplastic agents. Part 395. Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.

George Pettit; Jun-Ping Xu; Diane E. Gingrich; Michael D. Williams; Dennis L. Doubek; Jean Chapuis; Jean M. Schmidt

doi:10.1039/a902380a

Antineoplastic agents. Part 395. Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.

George Pettit, Jun-Ping Xu, Diane E. Gingrich, Michael D. Williams, Dennis L. Doubek, Jean Chapuis, Jean M. Schmidt

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge Agelas sp. led to isolation of a trace (7.42 x 10^-6% yield) cancer cell growth inhibitor (lung NCI-H460 GI₅₀ 0.77 μg m^-1 to ovary OVCAR-3 GI₅₀ 2.8 μg ml^-1) designated agelagalastatin 6; it is the first example of a natural product containing a digalactofuranosyl unit.

Original language	English (US)
Pages (from-to)	915-916
Number of pages	2
Journal	Chemical Communications
Issue number	10
DOIs	https://doi.org/10.1039/a902380a
State	Published - May 21 1999

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/a902380a

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abstract = "A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge Agelas sp. led to isolation of a trace (7.42 x 10-6% yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 μg m-1 to ovary OVCAR-3 GI50 2.8 μg ml-1) designated agelagalastatin 6; it is the first example of a natural product containing a digalactofuranosyl unit.",

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AU - Williams, Michael D.

AU - Doubek, Dennis L.

AU - Chapuis, Jean

AU - Schmidt, Jean M.

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Antineoplastic agents. Part 395. Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.

Abstract

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