Antineoplastic agents. 67. senecio fendleri gray

George Pettit; James J. Einck; Peter Brown; Thomas B. Harvey; Richard H. Ode; Charles P. Pase

doi:10.1021/np50011a014

Antineoplastic agents. 67. senecio fendleri gray

George Pettit, James J. Einck, Peter Brown, Thomas B. Harvey, Richard H. Ode, Charles P. Pase

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A prominent anticancer constituent of the subalpine Rocky Mountain plant Senecio fendleri Gray was found to be the ethyl ester counterpart (1a) of Jacaranone. The structure of ethyl α-[4-(4-hydroxy-cyclohexa-2,5-dien-1-one)]-acetate (1a) was established by spectral (principally nuclear magnetic resonance and mass spectrometry) analysis and transformation to azobenzene 3. An x-ray crystal structure determination of the latter substance (3) confirmed the overall assignments.

Original language	English (US)
Pages (from-to)	609-616
Number of pages	8
Journal	Journal of Natural Products
Volume	43
Issue number	5
DOIs	https://doi.org/10.1021/np50011a014
State	Published - Sep 1980

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50011a014

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abstract = "A prominent anticancer constituent of the subalpine Rocky Mountain plant Senecio fendleri Gray was found to be the ethyl ester counterpart (1a) of Jacaranone. The structure of ethyl α-[4-(4-hydroxy-cyclohexa-2,5-dien-1-one)]-acetate (1a) was established by spectral (principally nuclear magnetic resonance and mass spectrometry) analysis and transformation to azobenzene 3. An x-ray crystal structure determination of the latter substance (3) confirmed the overall assignments.",

author = "George Pettit and Einck, {James J.} and Peter Brown and Harvey, {Thomas B.} and Ode, {Richard H.} and Pase, {Charles P.}",

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T1 - Antineoplastic agents. 67. senecio fendleri gray

AU - Pettit, George

AU - Einck, James J.

AU - Brown, Peter

AU - Harvey, Thomas B.

AU - Ode, Richard H.

AU - Pase, Charles P.

PY - 1980/9

Y1 - 1980/9

N2 - A prominent anticancer constituent of the subalpine Rocky Mountain plant Senecio fendleri Gray was found to be the ethyl ester counterpart (1a) of Jacaranone. The structure of ethyl α-[4-(4-hydroxy-cyclohexa-2,5-dien-1-one)]-acetate (1a) was established by spectral (principally nuclear magnetic resonance and mass spectrometry) analysis and transformation to azobenzene 3. An x-ray crystal structure determination of the latter substance (3) confirmed the overall assignments.

AB - A prominent anticancer constituent of the subalpine Rocky Mountain plant Senecio fendleri Gray was found to be the ethyl ester counterpart (1a) of Jacaranone. The structure of ethyl α-[4-(4-hydroxy-cyclohexa-2,5-dien-1-one)]-acetate (1a) was established by spectral (principally nuclear magnetic resonance and mass spectrometry) analysis and transformation to azobenzene 3. An x-ray crystal structure determination of the latter substance (3) confirmed the overall assignments.

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IS - 5

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Antineoplastic agents. 67. senecio fendleri gray

Abstract

ASJC Scopus subject areas

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