Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian ocean sponge Hyrtios erecta

George Pettit, Rui Tan, Zbigniew Cichacz

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 × 10-7% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED50 0.17 μg/mL, GI50 1.8-8.9 × 10-1 μg/mL) and proved to be the most inhibitory of the series.

Original languageEnglish (US)
Pages (from-to)1253-1255
Number of pages3
JournalJournal of Natural Products
Volume68
Issue number8
DOIs
StatePublished - Aug 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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