Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian ocean sponge Hyrtios erecta

George Pettit; Rui Tan; Zbigniew Cichacz

doi:10.1021/np0402221

Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian ocean sponge Hyrtios erecta

George Pettit, Rui Tan, Zbigniew Cichacz

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Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 × 10^-7% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED₅₀ 0.17 μg/mL, GI₅₀ 1.8-8.9 × 10^-1 μg/mL) and proved to be the most inhibitory of the series.

Original language	English (US)
Pages (from-to)	1253-1255
Number of pages	3
Journal	Journal of Natural Products
Volume	68
Issue number	8
DOIs	https://doi.org/10.1021/np0402221
State	Published - Aug 2005

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian ocean sponge Hyrtios erecta",

abstract = "A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 × 10-7% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED50 0.17 μg/mL, GI50 1.8-8.9 × 10-1 μg/mL) and proved to be the most inhibitory of the series.",

author = "George Pettit and Rui Tan and Zbigniew Cichacz",

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language = "English (US)",

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AU - Tan, Rui

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PY - 2005/8

Y1 - 2005/8

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AB - A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 × 10-7% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED50 0.17 μg/mL, GI50 1.8-8.9 × 10-1 μg/mL) and proved to be the most inhibitory of the series.

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Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian ocean sponge Hyrtios erecta

Abstract

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