Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a chuuk archipelago marine sponge

George Pettit, Rui Tan

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

A new cancer cell growth inhibitory (P388 lymphocytic leukemia ED50 2.8 μg/mL) cyclodecapeptide designated phakellistatin 12 (2) has been isolated as a trace (1.7×10-6% yield) constituent of the Western Pacific Ocean (Federated States of Micronesia-Chuuk) sponge Phakellia sp. Employing principally a combination of high resolution FAB with high field (500 MHz) 1H, 13C and 2-D NMR and chiral GC analyses the structure (all S chirality) cyclo-Ile-Phe-Thr-Leu-Pro-Pro-Tyr-Ile-Pro-Pro was assigned.

Original languageEnglish (US)
Pages (from-to)685-688
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number4
DOIs
StatePublished - Feb 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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