@article{225f0ccd33aa4a949b02f3899c29bfa9,
title = "Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a chuuk archipelago marine sponge",
abstract = "A new cancer cell growth inhibitory (P388 lymphocytic leukemia ED50 2.8 μg/mL) cyclodecapeptide designated phakellistatin 12 (2) has been isolated as a trace (1.7×10-6% yield) constituent of the Western Pacific Ocean (Federated States of Micronesia-Chuuk) sponge Phakellia sp. Employing principally a combination of high resolution FAB with high field (500 MHz) 1H, 13C and 2-D NMR and chiral GC analyses the structure (all S chirality) cyclo-Ile-Phe-Thr-Leu-Pro-Pro-Tyr-Ile-Pro-Pro was assigned.",
author = "George Pettit and Rui Tan",
note = "Funding Information: The success of this research was greatly aided by the following financial assistance: Outstanding Investigator Grant CA44344-01A1-08 awarded by the Division of Cancer Treatment, National Cancer Institute, DHHS; the Fannie E. Rippel Foundation; the Arizona Disease Control Researach Commission; the Robert B. Dalton Endowment Fund; Eleanor W. Libby; Diane Cummings Halle; Gary and Diane Tooker, John and Edith Reyno, and Polly J. Trautman. For other very helpful assistance we thank the Federated States of Micronesia (Chuuk, D. E. Aten, R. Killion, and A. Amaraich) and Drs. Donald L. Cerny, Matthew Suffness, Fiona Hogan, Cherry L. Herald, Jean M. Schmidt, Dennis L. Doubek, Messrs. Lee Williams and David M. Carnell. The four-sector tandem mass spectrometer used in these studies was purchased with funds awarded by the former NSF regional instrumentation program at the University of Nebraska-Lincoln. Additional support was provided by the NSF Biology Division (Dir-9017262). ",
year = "2003",
month = feb,
doi = "10.1016/S0960-894X(02)01054-5",
language = "English (US)",
volume = "13",
pages = "685--688",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "4",
}