Antineoplastic agents 365. Dolastatin 10 SAR probes

George Pettit, Jayaram K. Srirangam, Jozsef Barkoczy, Michael D. Williams, Michael R. Boyd, Ernest Hamel, Robin Pettit, Fiona Hogan, Ruoli Bai, Jean Chapuis, Shane C. McAllister, Jean M. Schmidt

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The remarkable anticancer drug dolastatin 10 (1a) from the Indian Ocean sea hare Dolabella auricularia is currently undergoing phase I clinical trials. Thirty-eight new structural modifications of this unusual peptide have been synthesized and evaluated against a variety of human and murine cancer cell lines, and for their ability to inhibit tubulin polymerization and vinblastine and GTP binding to tubulin. Dolastatin 10 and one structural modification was found to have antifungal activity, while one other structural modification of the parent compound exhibited antibacterial activity. Some of the new peptides approximated the antineoplastic potency of dolastatin 10, especially those based on replacement of the Doe unit with Met, Phe or an appropriately substituted phenylethylamide.

Original languageEnglish (US)
Pages (from-to)243-277
Number of pages35
JournalAnti-Cancer Drug Design
Volume13
Issue number4
StatePublished - Jun 1998

Keywords

  • Antineoplastic agents
  • Dolastatin 10
  • Structural modifications

ASJC Scopus subject areas

  • Biochemistry
  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Pettit, G., Srirangam, J. K., Barkoczy, J., Williams, M. D., Boyd, M. R., Hamel, E., Pettit, R., Hogan, F., Bai, R., Chapuis, J., McAllister, S. C., & Schmidt, J. M. (1998). Antineoplastic agents 365. Dolastatin 10 SAR probes. Anti-Cancer Drug Design, 13(4), 243-277.