Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana

George Pettit; James McNulty; Delbert L. Herald; Dennis L. Doubek; Jean Chapuis; Jean M. Schmidt; Larry P. Tackett; Michael R. Boyd

doi:10.1021/np9606106

Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana

George Pettit, James McNulty, Delbert L. Herald, Dennis L. Doubek, Jean Chapuis, Jean M. Schmidt, Larry P. Tackett, Michael R. Boyd

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialesine (2), thymidine, deoxyuridine, and thymine.

Original language	English (US)
Pages (from-to)	180-183
Number of pages	4
Journal	Journal of Natural Products
Volume	60
Issue number	2
DOIs	https://doi.org/10.1021/np9606106
State	Published - 1997

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np9606106

Cite this

@article{09243e728cee49418dde443967aaf473,

title = "Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana",

abstract = "Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialesine (2), thymidine, deoxyuridine, and thymine.",

author = "George Pettit and James McNulty and Herald, {Delbert L.} and Doubek, {Dennis L.} and Jean Chapuis and Schmidt, {Jean M.} and Tackett, {Larry P.} and Boyd, {Michael R.}",

year = "1997",

doi = "10.1021/np9606106",

language = "English (US)",

volume = "60",

pages = "180--183",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana

AU - Pettit, George

AU - McNulty, James

AU - Herald, Delbert L.

AU - Doubek, Dennis L.

AU - Chapuis, Jean

AU - Schmidt, Jean M.

AU - Tackett, Larry P.

AU - Boyd, Michael R.

PY - 1997

Y1 - 1997

N2 - Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialesine (2), thymidine, deoxyuridine, and thymine.

AB - Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialesine (2), thymidine, deoxyuridine, and thymine.

UR - http://www.scopus.com/inward/record.url?scp=0031019142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031019142&partnerID=8YFLogxK

U2 - 10.1021/np9606106

DO - 10.1021/np9606106

M3 - Article

C2 - 9051914

AN - SCOPUS:0031019142

SN - 0163-3864

VL - 60

SP - 180

EP - 183

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this