Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana

George Pettit, James McNulty, Delbert L. Herald, Dennis L. Doubek, Jean Chapuis, Jean M. Schmidt, Larry P. Tackett, Michael R. Boyd

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialesine (2), thymidine, deoxyuridine, and thymine.

Original languageEnglish (US)
Pages (from-to)180-183
Number of pages4
JournalJournal of Natural Products
Volume60
Issue number2
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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