Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp.

George Pettit; Rui Tan; Yoshitatsu Ichihara; Michael D. Williams; Dennis L. Doubek; Larry P. Tackett; Jean M. Schmidt; Ronald L. Cerny; Michael R. Boyd; John N A Hooper

doi:10.1021/np50120a025

Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp.

George Pettit, Rui Tan, Yoshitatsu Ichihara, Michael D. Williams, Dennis L. Doubek, Larry P. Tackett, Jean M. Schmidt, Ronald L. Cerny, Michael R. Boyd, John N A Hooper

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The two new marine sponge (Phakellia sp., western Pacific Ocean) constituents, phakellistatin 10 [1] and 11 [2], were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia (ED₅₀values of 2.1 and 0.20 μg/ ml, respectively) and human cancer cell lines. The structures were established based on results of extensive tandem ms/ms and high-field (500-MHz) 2D ¹H- and ¹³C-nmr analyses. All of the amino acid units (except Trp, not determined) were found to correspond to the (S)-configuration.

Original language	English (US)
Pages (from-to)	961-965
Number of pages	5
Journal	Journal of Natural Products
Volume	58
Issue number	6
DOIs	https://doi.org/10.1021/np50120a025
State	Published - Jun 1995

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np50120a025

Cite this

Pettit, G., Tan, R., Ichihara, Y., Williams, M. D., Doubek, D. L., Tackett, L. P., Schmidt, J. M., Cerny, R. L., Boyd, M. R., & Hooper, J. N. A. (1995). Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp. Journal of Natural Products, 58(6), 961-965. https://doi.org/10.1021/np50120a025

Pettit, G, Tan, R, Ichihara, Y, Williams, MD, Doubek, DL, Tackett, LP, Schmidt, JM, Cerny, RL, Boyd, MR & Hooper, JNA 1995, 'Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp.', Journal of Natural Products, vol. 58, no. 6, pp. 961-965. https://doi.org/10.1021/np50120a025

@article{b2c53da9012b476d8c08e4124ca16fa4,

title = "Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp.",

abstract = "The two new marine sponge (Phakellia sp., western Pacific Ocean) constituents, phakellistatin 10 [1] and 11 [2], were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia (ED50values of 2.1 and 0.20 μg/ ml, respectively) and human cancer cell lines. The structures were established based on results of extensive tandem ms/ms and high-field (500-MHz) 2D 1H- and 13C-nmr analyses. All of the amino acid units (except Trp, not determined) were found to correspond to the (S)-configuration.",

author = "George Pettit and Rui Tan and Yoshitatsu Ichihara and Williams, {Michael D.} and Doubek, {Dennis L.} and Tackett, {Larry P.} and Schmidt, {Jean M.} and Cerny, {Ronald L.} and Boyd, {Michael R.} and Hooper, {John N A}",

year = "1995",

month = jun,

doi = "10.1021/np50120a025",

language = "English (US)",

volume = "58",

pages = "961--965",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp.

AU - Pettit, George

AU - Tan, Rui

AU - Ichihara, Yoshitatsu

AU - Williams, Michael D.

AU - Doubek, Dennis L.

AU - Tackett, Larry P.

AU - Schmidt, Jean M.

AU - Cerny, Ronald L.

AU - Boyd, Michael R.

AU - Hooper, John N A

PY - 1995/6

Y1 - 1995/6

N2 - The two new marine sponge (Phakellia sp., western Pacific Ocean) constituents, phakellistatin 10 [1] and 11 [2], were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia (ED50values of 2.1 and 0.20 μg/ ml, respectively) and human cancer cell lines. The structures were established based on results of extensive tandem ms/ms and high-field (500-MHz) 2D 1H- and 13C-nmr analyses. All of the amino acid units (except Trp, not determined) were found to correspond to the (S)-configuration.

AB - The two new marine sponge (Phakellia sp., western Pacific Ocean) constituents, phakellistatin 10 [1] and 11 [2], were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia (ED50values of 2.1 and 0.20 μg/ ml, respectively) and human cancer cell lines. The structures were established based on results of extensive tandem ms/ms and high-field (500-MHz) 2D 1H- and 13C-nmr analyses. All of the amino acid units (except Trp, not determined) were found to correspond to the (S)-configuration.

UR - http://www.scopus.com/inward/record.url?scp=0029134951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029134951&partnerID=8YFLogxK

U2 - 10.1021/np50120a025

DO - 10.1021/np50120a025

M3 - Article

C2 - 7673945

AN - SCOPUS:0029134951

SN - 0163-3864

VL - 58

SP - 961

EP - 965

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp.

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this