Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia

George Pettit, Atsushi Numata, Tsuruko Takemura, Richard H. Ode, A. S. Narula, Jean M. Schmidt, Gordon M. Cragg, Charles P. Pase

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 μg/ml) and isoacteoside [2] (ED50 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.

Original languageEnglish (US)
Pages (from-to)456-458
Number of pages3
JournalJournal of Natural Products
Volume53
Issue number2
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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