Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia

George Pettit; Atsushi Numata; Tsuruko Takemura; Richard H. Ode; A. S. Narula; Jean M. Schmidt; Gordon M. Cragg; Charles P. Pase

doi:10.1021/np50068a026

Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia

George Pettit, Atsushi Numata, Tsuruko Takemura, Richard H. Ode, A. S. Narula, Jean M. Schmidt, Gordon M. Cragg, Charles P. Pase

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED₅₀ 2.6 μg/ml) and isoacteoside [2] (ED₅₀ 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.

Original language	English (US)
Pages (from-to)	456-458
Number of pages	3
Journal	Journal of Natural Products
Volume	53
Issue number	2
DOIs	https://doi.org/10.1021/np50068a026
State	Published - 1990

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50068a026

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title = "Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia",

abstract = "The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 μg/ml) and isoacteoside [2] (ED50 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.",

author = "George Pettit and Atsushi Numata and Tsuruko Takemura and Ode, {Richard H.} and Narula, {A. S.} and Schmidt, {Jean M.} and Cragg, {Gordon M.} and Pase, {Charles P.}",

year = "1990",

doi = "10.1021/np50068a026",

language = "English (US)",

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T1 - Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia

AU - Pettit, George

AU - Numata, Atsushi

AU - Takemura, Tsuruko

AU - Ode, Richard H.

AU - Narula, A. S.

AU - Schmidt, Jean M.

AU - Cragg, Gordon M.

AU - Pase, Charles P.

PY - 1990

Y1 - 1990

N2 - The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 μg/ml) and isoacteoside [2] (ED50 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.

AB - The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 μg/ml) and isoacteoside [2] (ED50 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.

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Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia

Abstract

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