Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure

G. Einecke, B. Sis, J. Reeve, M. Mengel, P. M. Campbell, L. G. Hidalgo, B. Kaplan, P. F. Halloran

Research output: Contribution to journalArticle

430 Citations (Scopus)

Abstract

We studied the phenotype of late kidney graft failure in a prospective study of unselected kidney transplant biopsies taken for clinical indications. We analyzed histopathology, HLA antibodies and death-censored graft survival in 234 consecutive biopsies from 173 patients, taken 6 days to 31 years posttransplant. Patients with late biopsies (>1 year) frequently displayed donor-specific HLA antibody (particularly class II) and microcirculation changes, including glomerulitis, glomerulopathy, capillaritis, capillary multilayering and C4d staining. Grafts biopsied early rarely failed (1/68), whereas grafts biopsied late often progressed to failure (27/105) within 3 years. T-cell-mediated rejection and its lesions were not associated with an increased risk of failure after biopsy. In multivariable analysis, graft failure correlated with microcirculation inflammation and scarring, but C4d staining was not significant. When microcirculation changes and HLA antibody were used to define antibody-mediated rejection, 17/27 (63%) of late kidney failures after biopsy were attributable to antibody-mediated rejection, but many were C4d negative and missed by current diagnostic criteria. Glomerulonephritis accounted for 6/27 late losses, whereas T-cell-mediated rejection, drug toxicity and unexplained scarring were uncommon. The major cause of late kidney transplant failure is antibody-mediated microcirculation injury, but detection of this phenotype requires new diagnostic criteria.

Original languageEnglish (US)
Pages (from-to)2520-2531
Number of pages12
JournalAmerican Journal of Transplantation
Volume9
Issue number11
DOIs
StatePublished - Nov 2009
Externally publishedYes

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Microcirculation
Renal Insufficiency
Transplants
Antibodies
Wounds and Injuries
Biopsy
Cicatrix
Staining and Labeling
T-Lymphocytes
Phenotype
Immunoglobulin Isotypes
Graft Survival
Glomerulonephritis
Drug-Related Side Effects and Adverse Reactions
Tissue Donors
Prospective Studies
Inflammation
Kidney

Keywords

  • Antibody-mediated rejection
  • C4d
  • HLA
  • Kidney
  • Renal allograft rejection
  • Transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Einecke, G., Sis, B., Reeve, J., Mengel, M., Campbell, P. M., Hidalgo, L. G., ... Halloran, P. F. (2009). Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. American Journal of Transplantation, 9(11), 2520-2531. https://doi.org/10.1111/j.1600-6143.2009.02799.x

Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. / Einecke, G.; Sis, B.; Reeve, J.; Mengel, M.; Campbell, P. M.; Hidalgo, L. G.; Kaplan, B.; Halloran, P. F.

In: American Journal of Transplantation, Vol. 9, No. 11, 11.2009, p. 2520-2531.

Research output: Contribution to journalArticle

Einecke, G, Sis, B, Reeve, J, Mengel, M, Campbell, PM, Hidalgo, LG, Kaplan, B & Halloran, PF 2009, 'Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure', American Journal of Transplantation, vol. 9, no. 11, pp. 2520-2531. https://doi.org/10.1111/j.1600-6143.2009.02799.x
Einecke, G. ; Sis, B. ; Reeve, J. ; Mengel, M. ; Campbell, P. M. ; Hidalgo, L. G. ; Kaplan, B. ; Halloran, P. F. / Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. In: American Journal of Transplantation. 2009 ; Vol. 9, No. 11. pp. 2520-2531.
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