Ancient genes establish stress-induced mutation as a hallmark of cancer

Luis Cisneros, Kimberly J. Bussey, Adam J. Orr, Milica Miočević, Charles H. Lineweaver, Paul Davies

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cancer is sometimes depicted as a reversion to single cell behavior in cells adapted to live in a multicellular assembly. If this is the case, one would expect that mutation in cancer disrupts functional mechanisms that suppress cell-level traits detrimental to multicellularity. Such mechanisms should have evolved with or after the emergence of multicellularity. This leads to two related, but distinct hypotheses: 1) Somatic mutations in cancer will occur in genes that are younger than the emergence of multicellularity (1000 million years [MY]); and 2) genes that are frequently mutated in cancer and whose mutations are functionally important for the emergence of the cancer phenotype evolved within the past 1000 million years, and thus would exhibit an age distribution that is skewed to younger genes. In order to investigate these hypotheses we estimated the evolutionary ages of all human genes and then studied the probability of mutation and their biological function in relation to their age and genomic location for both normal germline and cancer contexts. We observed that under a model of uniform random mutation across the genome, controlled for gene size, genes less than 500 MY were more frequently mutated in both cases. Paradoxically, causal genes, defined in the COSMIC Cancer Gene Census, were depleted in this age group. When we used functional enrichment analysis to explain this unexpected result we discovered that COSMIC genes with recessive disease phenotypes were enriched for DNA repair and cell cycle control. The non-mutated genes in these pathways are orthologous to those underlying stress-induced mutation in bacteria, which results in the clustering of single nucleotide variations. COSMIC genes were less common in regions where the probability of observing mutational clusters is high, although they are approximately 2-fold more likely to harbor mutational clusters compared to other human genes. Our results suggest this ancient mutational response to stress that evolved among prokaryotes was co-opted to maintain diversity in the germline and immune system, while the original phenotype is restored in cancer. Reversion to a stress-induced mutational response is a hallmark of cancer that allows for effectively searching "protected" genome space where genes causally implicated in cancer are located and underlies the high adaptive potential and concomitant therapeutic resistance that is characteristic of cancer.

Original languageEnglish (US)
Article numbere0176258
JournalPLoS One
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2017

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mutagenesis
Genes
Mutation
neoplasms
Neoplasms
genes
mutation
Phenotype
phenotype
germ cells
Genome
Recessive Genes
Neoplasm Genes
Age Distribution
Censuses
somatic mutation
Cell Cycle Checkpoints
genome
DNA Repair
cells

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Cisneros, L., Bussey, K. J., Orr, A. J., Miočević, M., Lineweaver, C. H., & Davies, P. (2017). Ancient genes establish stress-induced mutation as a hallmark of cancer. PLoS One, 12(4), [e0176258]. https://doi.org/10.1371/journal.pone.0176258

Ancient genes establish stress-induced mutation as a hallmark of cancer. / Cisneros, Luis; Bussey, Kimberly J.; Orr, Adam J.; Miočević, Milica; Lineweaver, Charles H.; Davies, Paul.

In: PLoS One, Vol. 12, No. 4, e0176258, 01.04.2017.

Research output: Contribution to journalArticle

Cisneros, L, Bussey, KJ, Orr, AJ, Miočević, M, Lineweaver, CH & Davies, P 2017, 'Ancient genes establish stress-induced mutation as a hallmark of cancer', PLoS One, vol. 12, no. 4, e0176258. https://doi.org/10.1371/journal.pone.0176258
Cisneros L, Bussey KJ, Orr AJ, Miočević M, Lineweaver CH, Davies P. Ancient genes establish stress-induced mutation as a hallmark of cancer. PLoS One. 2017 Apr 1;12(4). e0176258. https://doi.org/10.1371/journal.pone.0176258
Cisneros, Luis ; Bussey, Kimberly J. ; Orr, Adam J. ; Miočević, Milica ; Lineweaver, Charles H. ; Davies, Paul. / Ancient genes establish stress-induced mutation as a hallmark of cancer. In: PLoS One. 2017 ; Vol. 12, No. 4.
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