Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis

Earth & Environmental Sciences

• mutation 71%
• defect 62%
• pulmonary disease 57%
• genealogy 52%
• family 51%
• nineteenth century 40%
• allele 40%
• ancestry 38%
• mutant 38%
• chromosome 37%
• RNA 37%
• substitution 31%
• DNA 29%
• gene 27%
• loss 19%

Agriculture & Biology

• telomerase 100%
• fibrosis 87%
• telomeres 82%
• lungs 57%
• mutation 49%
• RNA-directed DNA polymerase 19%
• shortenings 16%
• idiopathic diseases 15%
• haploinsufficiency 13%
• pedigree 8%
• active sites 7%
• ancestry 6%
• germ cells 6%
• alleles 5%
• RNA 5%
• chromosomes 5%
• mutants 4%
• synthesis 4%
• DNA 4%
• genes 2%

Medicine & Life Sciences

• Pulmonary Fibrosis 82%
• Telomerase 82%
• Telomere 79%
• Mutation 40%
• Telomere Shortening 31%
• Telomere Homeostasis 17%
• Haploinsufficiency 15%
• Idiopathic Pulmonary Fibrosis 14%
• Germ-Line Mutation 13%
• Pedigree 13%
• Catalytic Domain 10%
• Chromosomes 9%
• Alleles 8%
• RNA 8%
• DNA 6%
• In Vitro Techniques 5%
• Genes 4%