Analysis of tumour ecological balance reveals resource-dependent adaptive strategies of ovarian cancer

Sidra Nawaz, Nicholas A. Trahearn, Andreas Heindl, Susana Banerjee, Carlo C. Maley, Andrea Sottoriva, Yinyin Yuan

Research output: Contribution to journalArticle

Abstract

Background: Despite treatment advances, there remains a significant risk of recurrence in ovarian cancer, at which stage it is usually incurable. Consequently, there is a clear need for improved patient stratification. However, at present clinical prognosticators remain largely unchanged due to the lack of reproducible methods to identify high-risk patients. Methods: In high-grade serous ovarian cancer patients with advanced disease, we spatially define a tumour ecological balance of stromal resource and immune hazard using high-throughput image and spatial analysis of routine histology slides. On this basis an EcoScore is developed to classify tumours by a shift in this balance towards cancer-favouring or inhibiting conditions. Findings: The EcoScore provides prognostic value stronger than, and independent of, known risk factors. Crucially, the clinical relevance of mutational burden and genomic instability differ under different stromal resource conditions, suggesting that the selective advantage of these cancer hallmarks is dependent on the context of stromal spatial structure. Under a high resource condition defined by a high level of geographical intermixing of cancer and stromal cells, selection appears to be driven by point mutations; whereas, in low resource tumours featured with high hypoxia and low cancer-immune co-localization, selection is fuelled by aneuploidy. Interpretation: Our study offers empirical evidence that cancer fitness depends on tumour spatial constraints, and presents a biological basis for developing better assessments of tumour adaptive strategies in overcoming ecological constraints including immune surveillance and hypoxia.

Original languageEnglish (US)
Pages (from-to)224-235
Number of pages12
JournalEBioMedicine
Volume48
DOIs
StatePublished - Oct 2019

Fingerprint

Ovarian Neoplasms
Tumors
Neoplasms
Histology
Hazards
Throughput
Spatial Analysis
Genomic Instability
Aneuploidy
Stromal Cells
Point Mutation
Recurrence

Keywords

  • Cancer evolution
  • Histological image analysis
  • Ovarian cancer
  • Tumour ecology
  • Tumour spatial heterogeneity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Analysis of tumour ecological balance reveals resource-dependent adaptive strategies of ovarian cancer. / Nawaz, Sidra; Trahearn, Nicholas A.; Heindl, Andreas; Banerjee, Susana; Maley, Carlo C.; Sottoriva, Andrea; Yuan, Yinyin.

In: EBioMedicine, Vol. 48, 10.2019, p. 224-235.

Research output: Contribution to journalArticle

Nawaz, Sidra ; Trahearn, Nicholas A. ; Heindl, Andreas ; Banerjee, Susana ; Maley, Carlo C. ; Sottoriva, Andrea ; Yuan, Yinyin. / Analysis of tumour ecological balance reveals resource-dependent adaptive strategies of ovarian cancer. In: EBioMedicine. 2019 ; Vol. 48. pp. 224-235.
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