Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection

Pablo M. Arce; Ruth Goldschmidt; Omar Khdour; Manikandadas M. Madathil; Jennifer Jaruvangsanti; Sriloy Dey; David M. Fash; Jeffrey S. Armstrong; Sidney Hecht

doi:10.1016/j.bmc.2012.07.005

Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection

Pablo M. Arce, Ruth Goldschmidt, Omar Khdour, Manikandadas M. Madathil, Jennifer Jaruvangsanti, Sriloy Dey, David M. Fash, Jeffrey S. Armstrong, Sidney Hecht

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Selected pyridinol analogues of the experimental neuroprotective drug idebenone have been synthesized and evaluated as antioxidants capable of preserving mitochondrial function. The compounds, having a different redox core but the same side chain as idebenone, exhibited a range of potencies, reflecting differences in their structures. The results obtained provide guidance in the design of such analogues with improved properties. Analogues were identified that have significantly improved antioxidant activity compared with idebenone in cultured lymphocytes, and which exhibit lesser inhibition of the electron transport chain.

Original language	English (US)
Pages (from-to)	5188-5201
Number of pages	14
Journal	Bioorganic and Medicinal Chemistry
Volume	20
Issue number	17
DOIs	https://doi.org/10.1016/j.bmc.2012.07.005
State	Published - Sep 1 2012

Keywords

Electron transport chain
Idebenone
Mitochondrial dysfunction
Reactive oxygen species

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2012.07.005

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Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection. / Arce, Pablo M.; Goldschmidt, Ruth; Khdour, Omar; Madathil, Manikandadas M.; Jaruvangsanti, Jennifer; Dey, Sriloy; Fash, David M.; Armstrong, Jeffrey S.; Hecht, Sidney.

In: Bioorganic and Medicinal Chemistry, Vol. 20, No. 17, 01.09.2012, p. 5188-5201.

Research output: Contribution to journal › Article › peer-review

Arce, Pablo M. ; Goldschmidt, Ruth ; Khdour, Omar ; Madathil, Manikandadas M. ; Jaruvangsanti, Jennifer ; Dey, Sriloy ; Fash, David M. ; Armstrong, Jeffrey S. ; Hecht, Sidney. / Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection. In: Bioorganic and Medicinal Chemistry. 2012 ; Vol. 20, No. 17. pp. 5188-5201.

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