Abstract
Selected pyridinol analogues of the experimental neuroprotective drug idebenone have been synthesized and evaluated as antioxidants capable of preserving mitochondrial function. The compounds, having a different redox core but the same side chain as idebenone, exhibited a range of potencies, reflecting differences in their structures. The results obtained provide guidance in the design of such analogues with improved properties. Analogues were identified that have significantly improved antioxidant activity compared with idebenone in cultured lymphocytes, and which exhibit lesser inhibition of the electron transport chain.
Original language | English (US) |
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Pages (from-to) | 5188-5201 |
Number of pages | 14 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 20 |
Issue number | 17 |
DOIs | |
State | Published - Sep 1 2012 |
Keywords
- Electron transport chain
- Idebenone
- Mitochondrial dysfunction
- Reactive oxygen species
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry