AMPylation of rho GTPases subverts multiple host signaling processes

Andrew R. Woolery, Xiaobo Yu, Joshua LaBaer, Kim Orth

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: VopS is a bacterial effector that AMPylates Rho GTPases.

Results: AMPylation of Rho GTPases inhibits their interaction with multiple downstream effectors.

Conclusion: VopS conducts a multifaceted host signaling inhibition program by targeting the critical Rho GTPases.

Significance: Broadens the understanding of how switch-1 modification of Rho GTPases affects host responses.

Original languageEnglish (US)
Pages (from-to)32977-32988
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number47
DOIs
StatePublished - Nov 21 2014

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rho GTP-Binding Proteins
Switches

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

AMPylation of rho GTPases subverts multiple host signaling processes. / Woolery, Andrew R.; Yu, Xiaobo; LaBaer, Joshua; Orth, Kim.

In: Journal of Biological Chemistry, Vol. 289, No. 47, 21.11.2014, p. 32977-32988.

Research output: Contribution to journalArticle

Woolery, Andrew R. ; Yu, Xiaobo ; LaBaer, Joshua ; Orth, Kim. / AMPylation of rho GTPases subverts multiple host signaling processes. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 47. pp. 32977-32988.
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