AMPylation of rho GTPases subverts multiple host signaling processes

Andrew R. Woolery, Xiaobo Yu, Joshua LaBaer, Kim Orth

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Background: VopS is a bacterial effector that AMPylates Rho GTPases.

Results: AMPylation of Rho GTPases inhibits their interaction with multiple downstream effectors.

Conclusion: VopS conducts a multifaceted host signaling inhibition program by targeting the critical Rho GTPases.

Significance: Broadens the understanding of how switch-1 modification of Rho GTPases affects host responses.

Original languageEnglish (US)
Pages (from-to)32977-32988
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number47
DOIs
StatePublished - Nov 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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