Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing

Madhan M.C.S. Jaggarapu; Deepanjan Ghosh; Tyler Johnston; Jordan R. Yaron; Joslyn L. Mangal; Sahil Inamdar; Mallikarjun Gosangi; Kaushal Rege; Abhinav P. Acharya

doi:10.1002/jbm.a.37539

Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing

Madhan M.C.S. Jaggarapu, Deepanjan Ghosh, Tyler Johnston, Jordan R. Yaron, Joslyn L. Mangal, Sahil Inamdar, Mallikarjun Gosangi, Kaushal Rege, Abhinav P. Acharya

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Metabolites are not only involved in energy pathways but can also act as signaling molecules. Herein, we demonstrate that polyesters of alpha-ketoglutararte (paKG) can be generated by reacting aKG with aliphatic diols of different lengths, which release aKG in a sustained manner. paKG polymer-based microparticles generated via emulsion-evaporation technique lead to faster keratinocyte wound closures in a scratch assay test. Moreover, paKG microparticles also led to faster wound healing responses in an excisional wound model in live mice. Overall, this study shows that paKG MPs that release aKG in a sustained manner can be used to develop regenerative therapeutic responses.

Original language	English (US)
Pages (from-to)	1372-1378
Number of pages	7
Journal	Journal of Biomedical Materials Research - Part A
Volume	111
Issue number	9
DOIs	https://doi.org/10.1002/jbm.a.37539
State	Published - Sep 2023

Keywords

TCA cycle
alpha-ketoglutarate
metabolism
microparticle
wound healing

ASJC Scopus subject areas

Ceramics and Composites
Biomaterials
Biomedical Engineering
Metals and Alloys

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10.1002/jbm.a.37539

Cite this

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title = "Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing",

abstract = "Metabolites are not only involved in energy pathways but can also act as signaling molecules. Herein, we demonstrate that polyesters of alpha-ketoglutararte (paKG) can be generated by reacting aKG with aliphatic diols of different lengths, which release aKG in a sustained manner. paKG polymer-based microparticles generated via emulsion-evaporation technique lead to faster keratinocyte wound closures in a scratch assay test. Moreover, paKG microparticles also led to faster wound healing responses in an excisional wound model in live mice. Overall, this study shows that paKG MPs that release aKG in a sustained manner can be used to develop regenerative therapeutic responses.",

keywords = "TCA cycle, alpha-ketoglutarate, metabolism, microparticle, wound healing",

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T1 - Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing

AU - Jaggarapu, Madhan M.C.S.

AU - Ghosh, Deepanjan

AU - Johnston, Tyler

AU - Yaron, Jordan R.

AU - Mangal, Joslyn L.

AU - Inamdar, Sahil

AU - Gosangi, Mallikarjun

AU - Rege, Kaushal

AU - Acharya, Abhinav P.

PY - 2023/9

Y1 - 2023/9

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AB - Metabolites are not only involved in energy pathways but can also act as signaling molecules. Herein, we demonstrate that polyesters of alpha-ketoglutararte (paKG) can be generated by reacting aKG with aliphatic diols of different lengths, which release aKG in a sustained manner. paKG polymer-based microparticles generated via emulsion-evaporation technique lead to faster keratinocyte wound closures in a scratch assay test. Moreover, paKG microparticles also led to faster wound healing responses in an excisional wound model in live mice. Overall, this study shows that paKG MPs that release aKG in a sustained manner can be used to develop regenerative therapeutic responses.

KW - TCA cycle

KW - alpha-ketoglutarate

KW - metabolism

KW - microparticle

KW - wound healing

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Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing

Abstract

Keywords

ASJC Scopus subject areas

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