A new cytotoxic principle, steroidal saponin afromontoside (1), has been isolated from a methanolic extract of the twigs of Dracaena afromontana. It was shown to be (25R)-furost-5-ene-3β,22α,26-triol 26-O-α-L- rhamnopyranoside 3-O-([O-α-L-rhamnopyranosyl(1→4)]-β-D- glucopyranoside) by spectral and chemical methods. The aglycone of afromontoside, diosgenin, as well as dihydrodiosgenin and several structurally related compounds have been shown to be cytotoxic to cultured KB cells.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|State||Published - Jan 1 1984|
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