Afromontoside. A new cytotoxic principle from Dracaena afromontana

K. Sambi Reddy, Mohammed S. Shekhani, David E. Berry, David G. Lynn, Sidney M. Hecht

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A new cytotoxic principle, steroidal saponin afromontoside (1), has been isolated from a methanolic extract of the twigs of Dracaena afromontana. It was shown to be (25R)-furost-5-ene-3β,22α,26-triol 26-O-α-L- rhamnopyranoside 3-O-([O-α-L-rhamnopyranosyl(1→4)]-β-D- glucopyranoside) by spectral and chemical methods. The aglycone of afromontoside, diosgenin, as well as dihydrodiosgenin and several structurally related compounds have been shown to be cytotoxic to cultured KB cells.

Original languageEnglish (US)
Pages (from-to)987-992
Number of pages6
JournalJournal of the Chemical Society, Perkin Transactions 1
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Chemistry(all)

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