TY - JOUR
T1 - Afromontoside. A new cytotoxic principle from Dracaena afromontana
AU - Reddy, K. Sambi
AU - Shekhani, Mohammed S.
AU - Berry, David E.
AU - Lynn, David G.
AU - Hecht, Sidney M.
PY - 1984
Y1 - 1984
N2 - A new cytotoxic principle, steroidal saponin afromontoside (1), has been isolated from a methanolic extract of the twigs of Dracaena afromontana. It was shown to be (25R)-furost-5-ene-3β,22α,26-triol 26-O-α-L- rhamnopyranoside 3-O-([O-α-L-rhamnopyranosyl(1→4)]-β-D- glucopyranoside) by spectral and chemical methods. The aglycone of afromontoside, diosgenin, as well as dihydrodiosgenin and several structurally related compounds have been shown to be cytotoxic to cultured KB cells.
AB - A new cytotoxic principle, steroidal saponin afromontoside (1), has been isolated from a methanolic extract of the twigs of Dracaena afromontana. It was shown to be (25R)-furost-5-ene-3β,22α,26-triol 26-O-α-L- rhamnopyranoside 3-O-([O-α-L-rhamnopyranosyl(1→4)]-β-D- glucopyranoside) by spectral and chemical methods. The aglycone of afromontoside, diosgenin, as well as dihydrodiosgenin and several structurally related compounds have been shown to be cytotoxic to cultured KB cells.
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U2 - 10.1039/p19840000987
DO - 10.1039/p19840000987
M3 - Article
AN - SCOPUS:37049092199
SN - 1472-7781
SP - 987
EP - 992
JO - Journal of the Chemical Society, Perkin Transactions 1
JF - Journal of the Chemical Society, Perkin Transactions 1
ER -