TY - JOUR
T1 - Administration of small doses of apomorphine attenuates feeding in non-deprived pigeons
AU - Deviche, P.
N1 - Funding Information:
Thanks are due to Prof. J. D. Delius for improvements of the original manuscript, and to Mrs. A. Lohmann and Mr. H. Stan-kewicz for varied help. The author was Senior Research Assistant at the Belgian National Fund for Scientific Research, and received an A. von Humboldt fellowship and a NATO grant. Work supported by the Deutsche Forschungsgemeinschaft through its Sonderfor-schungsbereich 114.
PY - 1984/10
Y1 - 1984/10
N2 - The dopamine agonist apomorphine was administered peripherally at small doses of 25, 50 or 100 μg to non-deprived pigeons, either in the morning or in the afternoon. The food and water consumption of the birds was then measured at 4 times (30, 60, 90 and 120 min) after the injection. In the control condition (injection of saline), the pigeons ate less in the morning than in the afternoon, whereas a reverse situation was observed for drinking. Administration of apomorphine attenuated the food consumption in a dose-related fashion, at both times of the day, and for no longer than 90 min post-injection; the reduction of feeding was relatively larger when the drug was given in the morning than in the afternoon, and it was not accompanied by consistent changes of the water consumption. These results show that in pigeons, the feeding-like responses to apomorphine treatment (pecking, swallowing, mandibulating) which have been described previously are not associated with an actual enhancement of the food intake. Possible mechanisms and loci of action of dopamine agonists on these 2 types of behaviors are discussed.
AB - The dopamine agonist apomorphine was administered peripherally at small doses of 25, 50 or 100 μg to non-deprived pigeons, either in the morning or in the afternoon. The food and water consumption of the birds was then measured at 4 times (30, 60, 90 and 120 min) after the injection. In the control condition (injection of saline), the pigeons ate less in the morning than in the afternoon, whereas a reverse situation was observed for drinking. Administration of apomorphine attenuated the food consumption in a dose-related fashion, at both times of the day, and for no longer than 90 min post-injection; the reduction of feeding was relatively larger when the drug was given in the morning than in the afternoon, and it was not accompanied by consistent changes of the water consumption. These results show that in pigeons, the feeding-like responses to apomorphine treatment (pecking, swallowing, mandibulating) which have been described previously are not associated with an actual enhancement of the food intake. Possible mechanisms and loci of action of dopamine agonists on these 2 types of behaviors are discussed.
KW - Apomorphine
KW - Dopamine
KW - Dopamine agonists
KW - Food intake
KW - Pecking
KW - Pigeons
KW - Stereotypy
KW - Water intake
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U2 - 10.1016/0031-9384(84)90375-5
DO - 10.1016/0031-9384(84)90375-5
M3 - Article
C2 - 6543011
AN - SCOPUS:0021690238
SN - 0031-9384
VL - 33
SP - 581
EP - 585
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 4
ER -