Adaptive evolution of multiple traits through multiple mutations at a single gene

Catherine R. Linnen, Yu Ping Poh, Brant K. Peterson, Rowan D H Barrett, Joanna G. Larson, Jeffrey Jensen, Hopi E. Hoekstra

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.

Original languageEnglish (US)
Pages (from-to)1312-1316
Number of pages5
JournalScience
Volume339
Issue number6125
DOIs
StatePublished - Mar 15 2013
Externally publishedYes

Fingerprint

Color
Light
Mutation
Peromyscus
Genes
Phenotype
Haplotypes
Soil
Population
Dasyproctidae
plasticine

ASJC Scopus subject areas

  • General

Cite this

Linnen, C. R., Poh, Y. P., Peterson, B. K., Barrett, R. D. H., Larson, J. G., Jensen, J., & Hoekstra, H. E. (2013). Adaptive evolution of multiple traits through multiple mutations at a single gene. Science, 339(6125), 1312-1316. https://doi.org/10.1126/science.1233213

Adaptive evolution of multiple traits through multiple mutations at a single gene. / Linnen, Catherine R.; Poh, Yu Ping; Peterson, Brant K.; Barrett, Rowan D H; Larson, Joanna G.; Jensen, Jeffrey; Hoekstra, Hopi E.

In: Science, Vol. 339, No. 6125, 15.03.2013, p. 1312-1316.

Research output: Contribution to journalArticle

Linnen, CR, Poh, YP, Peterson, BK, Barrett, RDH, Larson, JG, Jensen, J & Hoekstra, HE 2013, 'Adaptive evolution of multiple traits through multiple mutations at a single gene', Science, vol. 339, no. 6125, pp. 1312-1316. https://doi.org/10.1126/science.1233213
Linnen CR, Poh YP, Peterson BK, Barrett RDH, Larson JG, Jensen J et al. Adaptive evolution of multiple traits through multiple mutations at a single gene. Science. 2013 Mar 15;339(6125):1312-1316. https://doi.org/10.1126/science.1233213
Linnen, Catherine R. ; Poh, Yu Ping ; Peterson, Brant K. ; Barrett, Rowan D H ; Larson, Joanna G. ; Jensen, Jeffrey ; Hoekstra, Hopi E. / Adaptive evolution of multiple traits through multiple mutations at a single gene. In: Science. 2013 ; Vol. 339, No. 6125. pp. 1312-1316.
@article{fd47153ef8df4183853e6c17cfb62bbf,
title = "Adaptive evolution of multiple traits through multiple mutations at a single gene",
abstract = "The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.",
author = "Linnen, {Catherine R.} and Poh, {Yu Ping} and Peterson, {Brant K.} and Barrett, {Rowan D H} and Larson, {Joanna G.} and Jeffrey Jensen and Hoekstra, {Hopi E.}",
year = "2013",
month = "3",
day = "15",
doi = "10.1126/science.1233213",
language = "English (US)",
volume = "339",
pages = "1312--1316",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6125",

}

TY - JOUR

T1 - Adaptive evolution of multiple traits through multiple mutations at a single gene

AU - Linnen, Catherine R.

AU - Poh, Yu Ping

AU - Peterson, Brant K.

AU - Barrett, Rowan D H

AU - Larson, Joanna G.

AU - Jensen, Jeffrey

AU - Hoekstra, Hopi E.

PY - 2013/3/15

Y1 - 2013/3/15

N2 - The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.

AB - The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.

UR - http://www.scopus.com/inward/record.url?scp=84874963219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874963219&partnerID=8YFLogxK

U2 - 10.1126/science.1233213

DO - 10.1126/science.1233213

M3 - Article

VL - 339

SP - 1312

EP - 1316

JO - Science

JF - Science

SN - 0036-8075

IS - 6125

ER -