Activity of etoposide (VP-16) in human tumor cells under different growth conditions

Jean Charles Chapuis; Peter C. Keng; Dietmar W. Siemann

doi:10.1016/0360-3016(91)90123-L

Activity of etoposide (VP-16) in human tumor cells under different growth conditions

Jean Charles Chapuis, Peter C. Keng, Dietmar W. Siemann

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effect of etoposide (VP-16) on a human epidermoid carcinoma cell line (HEp3) has been evaluated under different growth conditions. A significant increase in resistance to this agent from exponential to unfed plateau cells has been observed. Variations in the cell cycle distribution appear not to be sufficient to explain the difference in cell killing. Rather, our studies suggest the presence of an important proportion of quiescent (Q) cells in the plateau phase cultures which may determine the treatment outcome.

Original language	English (US)
Pages (from-to)	373-375
Number of pages	3
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/0360-3016(91)90123-L
State	Published - Feb 1991
Externally published	Yes

Keywords

Etoposide
Nutrient status
Proliferation

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(91)90123-L

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title = "Activity of etoposide (VP-16) in human tumor cells under different growth conditions",

abstract = "The effect of etoposide (VP-16) on a human epidermoid carcinoma cell line (HEp3) has been evaluated under different growth conditions. A significant increase in resistance to this agent from exponential to unfed plateau cells has been observed. Variations in the cell cycle distribution appear not to be sufficient to explain the difference in cell killing. Rather, our studies suggest the presence of an important proportion of quiescent (Q) cells in the plateau phase cultures which may determine the treatment outcome.",

keywords = "Etoposide, Nutrient status, Proliferation",

author = "Chapuis, {Jean Charles} and Keng, {Peter C.} and Siemann, {Dietmar W.}",

note = "Funding Information: This work was supported by USPHS grant CA-36858. Jean Charles Chapuis was the recipient of a Fellowship from the Swiss National Science Foundation. Accepted for publication 24 August 1990. * Corning Glass Works, Coming, NY. + Bristol Laboratories, Evansville, IN.",

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doi = "10.1016/0360-3016(91)90123-L",

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T1 - Activity of etoposide (VP-16) in human tumor cells under different growth conditions

AU - Chapuis, Jean Charles

AU - Keng, Peter C.

AU - Siemann, Dietmar W.

N1 - Funding Information: This work was supported by USPHS grant CA-36858. Jean Charles Chapuis was the recipient of a Fellowship from the Swiss National Science Foundation. Accepted for publication 24 August 1990. * Corning Glass Works, Coming, NY. + Bristol Laboratories, Evansville, IN.

PY - 1991/2

Y1 - 1991/2

N2 - The effect of etoposide (VP-16) on a human epidermoid carcinoma cell line (HEp3) has been evaluated under different growth conditions. A significant increase in resistance to this agent from exponential to unfed plateau cells has been observed. Variations in the cell cycle distribution appear not to be sufficient to explain the difference in cell killing. Rather, our studies suggest the presence of an important proportion of quiescent (Q) cells in the plateau phase cultures which may determine the treatment outcome.

AB - The effect of etoposide (VP-16) on a human epidermoid carcinoma cell line (HEp3) has been evaluated under different growth conditions. A significant increase in resistance to this agent from exponential to unfed plateau cells has been observed. Variations in the cell cycle distribution appear not to be sufficient to explain the difference in cell killing. Rather, our studies suggest the presence of an important proportion of quiescent (Q) cells in the plateau phase cultures which may determine the treatment outcome.

KW - Etoposide

KW - Nutrient status

KW - Proliferation

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JF - International Journal of Radiation Oncology, Biology, Physics

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Activity of etoposide (VP-16) in human tumor cells under different growth conditions

Abstract

Keywords

ASJC Scopus subject areas

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