Activity of etoposide (VP-16) in human tumor cells under different growth conditions

Jean Charles Chapuis, Peter C. Keng, Dietmar W. Siemann

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The effect of etoposide (VP-16) on a human epidermoid carcinoma cell line (HEp3) has been evaluated under different growth conditions. A significant increase in resistance to this agent from exponential to unfed plateau cells has been observed. Variations in the cell cycle distribution appear not to be sufficient to explain the difference in cell killing. Rather, our studies suggest the presence of an important proportion of quiescent (Q) cells in the plateau phase cultures which may determine the treatment outcome.

Original languageEnglish (US)
Pages (from-to)373-375
Number of pages3
JournalInternational Journal of Radiation Oncology, Biology, Physics
Issue number2
StatePublished - Feb 1991
Externally publishedYes


  • Etoposide
  • Nutrient status
  • Proliferation

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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