A unidirectional DNA walker that moves autonomously along a track

Peng Yin; Hao Yan; Xiaoju G. Daniell; Andrew J. Turberfield; John H. Reif

doi:10.1002/anie.200460522

A unidirectional DNA walker that moves autonomously along a track

Peng Yin, Hao Yan, Xiaoju G. Daniell, Andrew J. Turberfield, John H. Reif

Research output: Contribution to journal › Article › peer-review

420 Scopus citations

Abstract

There's no turning back for an autonomous DNA walker that moves along a self-assembled track, driven by the hydrolysis of ATP. The track contains three anchorages (A, B, C) at which the walker (*), a six-nucleotide DNA fragment, can be bound (see figure). The motion of the walker is unidirectional. At each step it is ligated to the next anchorage, then cut from the previous one by a restriction endonuclease.

Original language	English (US)
Pages (from-to)	4906-4911
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	37
DOIs	https://doi.org/10.1002/anie.200460522
State	Published - Sep 20 2004
Externally published	Yes

Keywords

DNA
Molecular devices
Nanorobotics
Nanostructures
Self-assembly

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200460522

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AU - Reif, John H.

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KW - Nanorobotics

KW - Nanostructures

KW - Self-assembly

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A unidirectional DNA walker that moves autonomously along a track

Abstract

Keywords

ASJC Scopus subject areas

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