A strategy for suppressing redox stress within mitochondria

Pablo M. Arce, Omar Khdour, Ruth Goldschmidt, Jeffrey S. Armstrong, Sidney Hecht

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than α-tocopherol and potently suppresses reactive oxygen species in cells under oxidative stress. It is thought to do so via a catalytic cycle in which both forms of oxidative stress are suppressed simultaneously. Consequently, the compound effectively protects cultured CEM leukemia cells and Friedreich's ataxia fibroblasts from oxidative stress more effectively than idebenone or idebenol.

Original languageEnglish (US)
Pages (from-to)608-613
Number of pages6
JournalACS Medicinal Chemistry Letters
Volume2
Issue number8
DOIs
StatePublished - Aug 11 2011

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Keywords

  • Reactive oxygen species
  • electron transport chain
  • lipid peroxidation
  • mitochondria

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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