A strategy for suppressing redox stress within mitochondria

Pablo M. Arce, Omar Khdour, Ruth Goldschmidt, Jeffrey S. Armstrong, Sidney Hecht

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than α-tocopherol and potently suppresses reactive oxygen species in cells under oxidative stress. It is thought to do so via a catalytic cycle in which both forms of oxidative stress are suppressed simultaneously. Consequently, the compound effectively protects cultured CEM leukemia cells and Friedreich's ataxia fibroblasts from oxidative stress more effectively than idebenone or idebenol.

Original languageEnglish (US)
Pages (from-to)608-613
Number of pages6
JournalACS Medicinal Chemistry Letters
Volume2
Issue number8
DOIs
StatePublished - Aug 11 2011

Fingerprint

Mitochondria
Oxidative stress
Oxidation-Reduction
Oxidative Stress
Friedreich Ataxia
Tocopherols
Neuroprotective Agents
Fibroblasts
Lipid Peroxidation
Reactive Oxygen Species
Leukemia
Lipids
idebenone

Keywords

  • electron transport chain
  • lipid peroxidation
  • mitochondria
  • Reactive oxygen species

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Biochemistry

Cite this

A strategy for suppressing redox stress within mitochondria. / Arce, Pablo M.; Khdour, Omar; Goldschmidt, Ruth; Armstrong, Jeffrey S.; Hecht, Sidney.

In: ACS Medicinal Chemistry Letters, Vol. 2, No. 8, 11.08.2011, p. 608-613.

Research output: Contribution to journalArticle

Arce, Pablo M. ; Khdour, Omar ; Goldschmidt, Ruth ; Armstrong, Jeffrey S. ; Hecht, Sidney. / A strategy for suppressing redox stress within mitochondria. In: ACS Medicinal Chemistry Letters. 2011 ; Vol. 2, No. 8. pp. 608-613.
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