A Smoking Cessation Trial with Lobeline Sulfate: A Pilot Study

Elbert D. Glover, Scott Leischow, Stephen I. Rennard, Penny N. Glover, David Daughton, John N. Quiring, F. Howard Schneider, Peter J. Mione

Research output: Contribution to journalArticle

8 Scopus citations


Objective: To evaluate a sublingual formulation of lobeline sulfate for smoking cessation. Methods: Random assignment of 180 healthy smokers to treatment (n=90) or placebo (n=90). Treatment was self-administering a 7.5 mg lobeline sulfate sublingual or placebo tablet 9 times per day for 6 weeks. Results: No difference in cessation efficacy between placebo and active treatment. Among highly dependent smokers who completed the trial, there was a trend for higher cessation rates in the active group. Conclusion: This pilot study failed to demonstrate smoking-cessation efficacy. However, data suggest continued studies to evaluate lobeline sulfate for smoking cessation.

Original languageEnglish (US)
Pages (from-to)62-74
Number of pages13
JournalAmerican journal of health behavior
Issue number1
StatePublished - Jan 1 1998


ASJC Scopus subject areas

  • Health(social science)
  • Social Psychology
  • Public Health, Environmental and Occupational Health

Cite this

Glover, E. D., Leischow, S., Rennard, S. I., Glover, P. N., Daughton, D., Quiring, J. N., Howard Schneider, F., & Mione, P. J. (1998). A Smoking Cessation Trial with Lobeline Sulfate: A Pilot Study. American journal of health behavior, 22(1), 62-74.