A simple interfacial design of biomolecules to nano/micro-devices for highly sensitive and selective protein detection

Seokheun Choi; Junseok Chae

doi:10.1115/IMECE2009-12575

A simple interfacial design of biomolecules to nano/micro-devices for highly sensitive and selective protein detection

Seokheun Choi, Junseok Chae

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present a novel immobilization technique via physical adsorption of biomolecules onto a sensing surface. The immobilization technique utilizes the competitive nature of protein adsorption onto the surface, offering the selectivity and sensitivity in detecting a target molecule. The SPR (Surface Plasmon Resonance) sensorgrams show that three human serum proteins, albumin, Immunoglobulin G (IgG) and fibrinogen, have different adsorption strengths to the surface and the competitive adsorption of individuals controls the exchange sequence. Using the competitive adsorption and exchange, we demonstrate that IgG is selectively and sensitively detected.

Original language	English (US)
Title of host publication	Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009
Publisher	American Society of Mechanical Engineers (ASME)
Pages	811-814
Number of pages	4
Edition	PART B
ISBN (Print)	9780791843857
DOIs	https://doi.org/10.1115/IMECE2009-12575
State	Published - 2010
Event	ASME 2009 International Mechanical Engineering Congress and Exposition, IMECE2009 - Lake Buena Vista, FL, United States Duration: Nov 13 2009 → Nov 19 2009

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings
Number	PART B
Volume	12

Other

Other	ASME 2009 International Mechanical Engineering Congress and Exposition, IMECE2009
Country/Territory	United States
City	Lake Buena Vista, FL
Period	11/13/09 → 11/19/09

ASJC Scopus subject areas

Mechanical Engineering

Access to Document

10.1115/IMECE2009-12575

Cite this

Choi, S., & Chae, J. (2010). A simple interfacial design of biomolecules to nano/micro-devices for highly sensitive and selective protein detection. In Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009 (PART B ed., pp. 811-814). (ASME International Mechanical Engineering Congress and Exposition, Proceedings; Vol. 12, No. PART B). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2009-12575

A simple interfacial design of biomolecules to nano/micro-devices for highly sensitive and selective protein detection. / Choi, Seokheun; Chae, Junseok.
Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009. PART B. ed. American Society of Mechanical Engineers (ASME), 2010. p. 811-814 (ASME International Mechanical Engineering Congress and Exposition, Proceedings; Vol. 12, No. PART B).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Choi, S & Chae, J 2010, A simple interfacial design of biomolecules to nano/micro-devices for highly sensitive and selective protein detection. in Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009. PART B edn, ASME International Mechanical Engineering Congress and Exposition, Proceedings, no. PART B, vol. 12, American Society of Mechanical Engineers (ASME), pp. 811-814, ASME 2009 International Mechanical Engineering Congress and Exposition, IMECE2009, Lake Buena Vista, FL, United States, 11/13/09. https://doi.org/10.1115/IMECE2009-12575

Choi S, Chae J. A simple interfacial design of biomolecules to nano/micro-devices for highly sensitive and selective protein detection. In Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009. PART B ed. American Society of Mechanical Engineers (ASME). 2010. p. 811-814. (ASME International Mechanical Engineering Congress and Exposition, Proceedings; PART B). doi: 10.1115/IMECE2009-12575

Choi, Seokheun ; Chae, Junseok. / A simple interfacial design of biomolecules to nano/micro-devices for highly sensitive and selective protein detection. Proceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009. PART B. ed. American Society of Mechanical Engineers (ASME), 2010. pp. 811-814 (ASME International Mechanical Engineering Congress and Exposition, Proceedings; PART B).

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A simple interfacial design of biomolecules to nano/micro-devices for highly sensitive and selective protein detection

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