A simple interfacial design of biomolecules to nano/micro-devices for highly sensitive and selective protein detection

Seokheun Choi, Junseok Chae

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a novel immobilization technique via physical adsorption of biomolecules onto a sensing surface. The immobilization technique utilizes the competitive nature of protein adsorption onto the surface, offering the selectivity and sensitivity in detecting a target molecule. The SPR (Surface Plasmon Resonance) sensorgrams show that three human serum proteins, albumin, Immunoglobulin G (IgG) and fibrinogen, have different adsorption strengths to the surface and the competitive adsorption of individuals controls the exchange sequence. Using the competitive adsorption and exchange, we demonstrate that IgG is selectively and sensitively detected.

Original languageEnglish (US)
Title of host publicationProceedings of the ASME International Mechanical Engineering Congress and Exposition 2009, IMECE 2009
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages811-814
Number of pages4
EditionPART B
ISBN (Print)9780791843857
DOIs
StatePublished - 2010
EventASME 2009 International Mechanical Engineering Congress and Exposition, IMECE2009 - Lake Buena Vista, FL, United States
Duration: Nov 13 2009Nov 19 2009

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings
NumberPART B
Volume12

Other

OtherASME 2009 International Mechanical Engineering Congress and Exposition, IMECE2009
CountryUnited States
CityLake Buena Vista, FL
Period11/13/0911/19/09

ASJC Scopus subject areas

  • Mechanical Engineering

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