A reagent resource to identify proteins and peptides of interest for the cancer community

Brian B. Haab, Amanda G. Paulovich, N. Leigh Anderson, Adam M. Clark, Gregory J. Downing, Henning Hermajakob, Joshua LaBaer, Mathias Uhlen

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

On the basis of discussions with representatives from all sectors of the cancer research community, the National Cancer Institute (NCI) recognizes the immense opportunities to apply proteomics technologies to further cancer research. Validated and well characterized affinity capture reagents (e.g. antibodies, aptamers, and affibodies) will play a key role in proteomics research platforms for the prevention, early detection, treatment, and monitoring of cancer. To discuss ways to develop new resources and optimize current opportunities in this area, the NCI convened the "Proteomic Technologies Reagents Resource Workshop" in Chicago, IL on December 12-13, 2005. The workshop brought together leading scientists in proteomics research to discuss model systems for evaluating and delivering resources for reagents to support MS and affinity capture platforms. Speakers discussed issues and identified action items related to an overall vision for and proposed models for a shared proteomics reagents resource, applications of affinity capture methods in cancer research, quality control and validation of affinity capture reagents, considerations for target selection, and construction of a reagents database. The meeting also featured presentations and discussion from leading private sector investigators on state-of-the-art technologies and capabilities to meet the user community's needs. This workshop was developed as a component of the NCI's Clinical Proteomics Technologies Initiative for Cancer, a coordinated initiative that includes the establishment of reagent resources for the scientific community. This workshop report explores various approaches to develop a framework that will most effectively fulfill the needs of the NCI and the cancer research community.

Original languageEnglish (US)
Pages (from-to)1996-2007
Number of pages12
JournalMolecular and Cellular Proteomics
Volume5
Issue number10
DOIs
StatePublished - Oct 2006
Externally publishedYes

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Proteomics
Peptides
National Cancer Institute (U.S.)
Research
Neoplasms
Proteins
Technology
Education
Private Sector
Quality Control
Quality control
Research Personnel
Databases
Antibodies
Monitoring

ASJC Scopus subject areas

  • Biochemistry

Cite this

Haab, B. B., Paulovich, A. G., Leigh Anderson, N., Clark, A. M., Downing, G. J., Hermajakob, H., ... Uhlen, M. (2006). A reagent resource to identify proteins and peptides of interest for the cancer community. Molecular and Cellular Proteomics, 5(10), 1996-2007. https://doi.org/10.1074/mcp.T600020-MCP200

A reagent resource to identify proteins and peptides of interest for the cancer community. / Haab, Brian B.; Paulovich, Amanda G.; Leigh Anderson, N.; Clark, Adam M.; Downing, Gregory J.; Hermajakob, Henning; LaBaer, Joshua; Uhlen, Mathias.

In: Molecular and Cellular Proteomics, Vol. 5, No. 10, 10.2006, p. 1996-2007.

Research output: Contribution to journalArticle

Haab, BB, Paulovich, AG, Leigh Anderson, N, Clark, AM, Downing, GJ, Hermajakob, H, LaBaer, J & Uhlen, M 2006, 'A reagent resource to identify proteins and peptides of interest for the cancer community', Molecular and Cellular Proteomics, vol. 5, no. 10, pp. 1996-2007. https://doi.org/10.1074/mcp.T600020-MCP200
Haab BB, Paulovich AG, Leigh Anderson N, Clark AM, Downing GJ, Hermajakob H et al. A reagent resource to identify proteins and peptides of interest for the cancer community. Molecular and Cellular Proteomics. 2006 Oct;5(10):1996-2007. https://doi.org/10.1074/mcp.T600020-MCP200
Haab, Brian B. ; Paulovich, Amanda G. ; Leigh Anderson, N. ; Clark, Adam M. ; Downing, Gregory J. ; Hermajakob, Henning ; LaBaer, Joshua ; Uhlen, Mathias. / A reagent resource to identify proteins and peptides of interest for the cancer community. In: Molecular and Cellular Proteomics. 2006 ; Vol. 5, No. 10. pp. 1996-2007.
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