A label-free optical detection method for biosensors and microfluidics

Xiaonan Shan; Kyle J. Foley; Nongjian Tao

doi:10.1063/1.2906486

A label-free optical detection method for biosensors and microfluidics

Xiaonan Shan, Kyle J. Foley, Nongjian Tao

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A label-free detection method is developed for biosensors and for microfluidic applications. Multiple optical modes, including a conventional surface plasmon resonance (SPR) mode and many bulk modes, are created in a microfluidic channel with metallic coatings on top and bottom. The bulk modes are bulk sensitive and detect analytes in the channel with 20 times higher sensitivity than the SPR, which is particularly suitable for microfluidic devices. The method can be operated either in the SPR mode for detection of molecular binding on a surface or in one of the bulk optical modes for monitoring analytes in the channel.

Original language	English (US)
Article number	133901
Journal	Applied Physics Letters
Volume	92
Issue number	13
DOIs	https://doi.org/10.1063/1.2906486
State	Published - 2008

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2906486

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abstract = "A label-free detection method is developed for biosensors and for microfluidic applications. Multiple optical modes, including a conventional surface plasmon resonance (SPR) mode and many bulk modes, are created in a microfluidic channel with metallic coatings on top and bottom. The bulk modes are bulk sensitive and detect analytes in the channel with 20 times higher sensitivity than the SPR, which is particularly suitable for microfluidic devices. The method can be operated either in the SPR mode for detection of molecular binding on a surface or in one of the bulk optical modes for monitoring analytes in the channel.",

author = "Xiaonan Shan and Foley, {Kyle J.} and Nongjian Tao",

note = "Funding Information: We would like to thank NSF (No. CHM-0554786) for financial support.",

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AU - Shan, Xiaonan

AU - Foley, Kyle J.

AU - Tao, Nongjian

N1 - Funding Information: We would like to thank NSF (No. CHM-0554786) for financial support.

PY - 2008

Y1 - 2008

N2 - A label-free detection method is developed for biosensors and for microfluidic applications. Multiple optical modes, including a conventional surface plasmon resonance (SPR) mode and many bulk modes, are created in a microfluidic channel with metallic coatings on top and bottom. The bulk modes are bulk sensitive and detect analytes in the channel with 20 times higher sensitivity than the SPR, which is particularly suitable for microfluidic devices. The method can be operated either in the SPR mode for detection of molecular binding on a surface or in one of the bulk optical modes for monitoring analytes in the channel.

AB - A label-free detection method is developed for biosensors and for microfluidic applications. Multiple optical modes, including a conventional surface plasmon resonance (SPR) mode and many bulk modes, are created in a microfluidic channel with metallic coatings on top and bottom. The bulk modes are bulk sensitive and detect analytes in the channel with 20 times higher sensitivity than the SPR, which is particularly suitable for microfluidic devices. The method can be operated either in the SPR mode for detection of molecular binding on a surface or in one of the bulk optical modes for monitoring analytes in the channel.

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A label-free optical detection method for biosensors and microfluidics

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