A generalized-growth model to characterize the early ascending phase of infectious disease outbreaks

Cécile Viboud, Lone Simonsen, Gerardo Chowell

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: A better characterization of the early growth dynamics of an epidemic is needed to dissect the important drivers of disease transmission, refine existing transmission models, and improve disease forecasts. Materials and methods: We introduce a 2-parameter generalized-growth model to characterize the ascending phase of an outbreak and capture epidemic profiles ranging from sub-exponential to exponential growth. We test the model against empirical outbreak data representing a variety of viral pathogens in historic and contemporary populations, and provide simulations highlighting the importance of sub-exponential growth for forecasting purposes. Results: We applied the generalized-growth model to 20 infectious disease outbreaks representing a range of transmission routes. We uncovered epidemic profiles ranging from very slow growth (p = 0.14 for the Ebola outbreak in Bomi, Liberia (2014)) to near exponential (p > 0.9 for the smallpox outbreak in Khulna (1972), and the 1918 pandemic influenza in San Francisco). The foot-and-mouth disease outbreak in Uruguay displayed a profile of slower growth while the growth pattern of the HIV/AIDS epidemic in Japan was approximately linear. The West African Ebola epidemic provided a unique opportunity to explore how growth profiles vary by geography; analysis of the largest district-level outbreaks revealed substantial growth variations (mean p = 0.59, range: 0.14-0.97). The districts of Margibi in Liberia and Bombali and Bo in Sierra Leone had near-exponential growth, while the districts of Bomi in Liberia and Kenema in Sierra Leone displayed near constant incidences. Conclusions: Our findings reveal significant variation in epidemic growth patterns across different infectious disease outbreaks and highlights that sub-exponential growth is a common phenomenon, especially for pathogens that are not airborne. Sub-exponential growth profiles may result from heterogeneity in contact structures or risk groups, reactive behavior changes, or the early onset of interventions strategies, and consideration of "deceleration parameters" may be useful to refine existing mathematical transmission models and improve disease forecasts.

Original languageEnglish (US)
Pages (from-to)27-37
Number of pages11
JournalEpidemics
Volume15
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Disease Outbreaks
Growth
Liberia
Sierra Leone
Uruguay
Foot-and-Mouth Disease
Geography
Smallpox
San Francisco
Deceleration
Pandemics
Human Influenza
Japan
Acquired Immunodeficiency Syndrome
Theoretical Models
HIV

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Microbiology
  • Parasitology
  • Virology

Cite this

A generalized-growth model to characterize the early ascending phase of infectious disease outbreaks. / Viboud, Cécile; Simonsen, Lone; Chowell, Gerardo.

In: Epidemics, Vol. 15, 01.06.2016, p. 27-37.

Research output: Contribution to journalArticle

Viboud, Cécile ; Simonsen, Lone ; Chowell, Gerardo. / A generalized-growth model to characterize the early ascending phase of infectious disease outbreaks. In: Epidemics. 2016 ; Vol. 15. pp. 27-37.
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