TY - JOUR
T1 - A concise synthesis of substituted 4-alkylaminopyrazolo[3,4-d]pyrimidines
AU - Hecht, Sidney M.
AU - Werner, Dieter
PY - 1973
Y1 - 1973
N2 - 4-Alkylamino-1-methylpyrazolo[3,4-d]pyrimidine-3-carbonitriles have been synthesised in 54-81% yields by condensation of N-substituted amides with 5-amino-1-methylpyrazole-3,4-dicarbonitrile via a Dimroth rearrangement in what is formally an anhydrous medium; the procedure thus permits the synthesis of pyrazolo[3,4-d]-pyrimidines with substituents sensitive to hydration.
AB - 4-Alkylamino-1-methylpyrazolo[3,4-d]pyrimidine-3-carbonitriles have been synthesised in 54-81% yields by condensation of N-substituted amides with 5-amino-1-methylpyrazole-3,4-dicarbonitrile via a Dimroth rearrangement in what is formally an anhydrous medium; the procedure thus permits the synthesis of pyrazolo[3,4-d]-pyrimidines with substituents sensitive to hydration.
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U2 - 10.1039/p19730001903
DO - 10.1039/p19730001903
M3 - Article
C2 - 4796656
AN - SCOPUS:0015870432
SN - 1472-7781
SP - 1903
EP - 1906
JO - Journal of the Chemical Society, Perkin Transactions 1
JF - Journal of the Chemical Society, Perkin Transactions 1
ER -