4-Alkylamino-1-methylpyrazolo[3,4-d]pyrimidine-3-carbonitriles have been synthesised in 54-81% yields by condensation of N-substituted amides with 5-amino-1-methylpyrazole-3,4-dicarbonitrile via a Dimroth rearrangement in what is formally an anhydrous medium; the procedure thus permits the synthesis of pyrazolo[3,4-d]-pyrimidines with substituents sensitive to hydration.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|State||Published - Jan 1 1973|
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