A computational model for asynchronous oocyte growth dynamics in a batch-spawning fish

Zhenhong Li, Daniel L. Villeneuve, Kathleen M. Jensen, Gerald T. Ankley, Karen Watanabe-Sailor

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A computational model of oocyte growth dynamics (i.e., oocyte recruitment, growth, and spawning) in a batch-spawning fish, fathead minnow (FHM, Pimephales promelas), has been developed. The model provides a quantitative link between oocyte growth dynamics and biochemical processes in FHMs through the absorption of vitellogenin (a lipoprotein precursor of egg yolk proteins) into oocytes, which contributes significantly to oocyte growth in fish. The model simulates the number and volume of oocytes in different batches within a FHM ovary. Model-predicted clutch sizes and spawning intervals matched the experimental data well for both unexposed FHMs and FHMs exposed to 17b-trenbolone (a relatively stable metabolite of trenbolone acetate, a synthetic androgen used as a growth promoter in livestock). Overall, the model presents a novel approach to simulating oocyte growth dynamics in a batch-spawning fish and meets an urgent need in ecotoxicological studies to link the effects of endocrine disrupting chemicals at a biochemical level to adverse effects upon reproduction.

Original languageEnglish (US)
Pages (from-to)1528-1538
Number of pages11
JournalCanadian Journal of Fisheries and Aquatic Sciences
Volume68
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Fingerprint

spawning
oocytes
fish
trenbolone
Pimephales promelas
synthetic androgens
androgen
yolk proteins
clutch size
endocrine-disrupting chemicals
vitellogenin
livestock
metabolite
acetate
lipoproteins
egg
adverse effects
protein
metabolites
effect

ASJC Scopus subject areas

  • Aquatic Science
  • Ecology, Evolution, Behavior and Systematics

Cite this

A computational model for asynchronous oocyte growth dynamics in a batch-spawning fish. / Li, Zhenhong; Villeneuve, Daniel L.; Jensen, Kathleen M.; Ankley, Gerald T.; Watanabe-Sailor, Karen.

In: Canadian Journal of Fisheries and Aquatic Sciences, Vol. 68, No. 9, 09.2011, p. 1528-1538.

Research output: Contribution to journalArticle

Li, Zhenhong ; Villeneuve, Daniel L. ; Jensen, Kathleen M. ; Ankley, Gerald T. ; Watanabe-Sailor, Karen. / A computational model for asynchronous oocyte growth dynamics in a batch-spawning fish. In: Canadian Journal of Fisheries and Aquatic Sciences. 2011 ; Vol. 68, No. 9. pp. 1528-1538.
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