A comprehensive human linkage map with centimorgan density

Jeffrey C. Murray; Kenneth H. Buetow; James L. Weber; Susan Ludwigsen; Titia Scherpbier-Heddema; Frank Manion; John Quillen; Val C. Sheffield; Sara Sunden; Geoffrey M. Duyk; Jean Weissenbach; Gabor Gyapay; Colette Dib; Jean Morrissette; G. Mark Lathrop; Alain Vignal; Ray White; Norisada Matsunami; Steven Gerken; Roberta Melis; Hans Albertsen; Rosemarie Plaetke; Shannon Odelberg; David Ward; Jean Dausset; Daniel Cohen; Howard Cann

doi:10.1126/science.8091227

A comprehensive human linkage map with centimorgan density

Jeffrey C. Murray, Kenneth H. Buetow, James L. Weber, Susan Ludwigsen, Titia Scherpbier-Heddema, Frank Manion, John Quillen, Val C. Sheffield, Sara Sunden, Geoffrey M. Duyk, Jean Weissenbach, Gabor Gyapay, Colette Dib, Jean Morrissette, G. Mark Lathrop, Alain Vignal, Ray White, Norisada Matsunami, Steven Gerken, Roberta MelisHans Albertsen, Rosemarie Plaetke, Shannon Odelberg, David Ward, Jean Dausset, Daniel Cohen, Howard Cann

Research output: Contribution to journal › Review article › peer-review

525 Scopus citations

Abstract

In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identity genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. It consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project - a comprehensive, high-density genetic map.

Original language	English (US)
Pages (from-to)	2049-2054
Number of pages	6
Journal	Science
Volume	265
Issue number	5181
DOIs	https://doi.org/10.1126/science.8091227
State	Published - Sep 30 1994
Externally published	Yes

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Murray, J. C., Buetow, K. H., Weber, J. L., Ludwigsen, S., Scherpbier-Heddema, T., Manion, F., Quillen, J., Sheffield, V. C., Sunden, S., Duyk, G. M., Weissenbach, J., Gyapay, G., Dib, C., Morrissette, J., Lathrop, G. M., Vignal, A., White, R., Matsunami, N., Gerken, S., ... Cann, H. (1994). A comprehensive human linkage map with centimorgan density. Science, 265(5181), 2049-2054. https://doi.org/10.1126/science.8091227

Murray, JC, Buetow, KH, Weber, JL, Ludwigsen, S, Scherpbier-Heddema, T, Manion, F, Quillen, J, Sheffield, VC, Sunden, S, Duyk, GM, Weissenbach, J, Gyapay, G, Dib, C, Morrissette, J, Lathrop, GM, Vignal, A, White, R, Matsunami, N, Gerken, S, Melis, R, Albertsen, H, Plaetke, R, Odelberg, S, Ward, D, Dausset, J, Cohen, D & Cann, H 1994, 'A comprehensive human linkage map with centimorgan density', Science, vol. 265, no. 5181, pp. 2049-2054. https://doi.org/10.1126/science.8091227

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title = "A comprehensive human linkage map with centimorgan density",

abstract = "In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identity genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. It consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project - a comprehensive, high-density genetic map.",

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doi = "10.1126/science.8091227",

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T1 - A comprehensive human linkage map with centimorgan density

AU - Murray, Jeffrey C.

AU - Buetow, Kenneth H.

AU - Weber, James L.

AU - Ludwigsen, Susan

AU - Scherpbier-Heddema, Titia

AU - Manion, Frank

AU - Quillen, John

AU - Sheffield, Val C.

AU - Sunden, Sara

AU - Duyk, Geoffrey M.

AU - Weissenbach, Jean

AU - Gyapay, Gabor

AU - Dib, Colette

AU - Morrissette, Jean

AU - Lathrop, G. Mark

AU - Vignal, Alain

AU - White, Ray

AU - Matsunami, Norisada

AU - Gerken, Steven

AU - Melis, Roberta

AU - Albertsen, Hans

AU - Plaetke, Rosemarie

AU - Odelberg, Shannon

AU - Ward, David

AU - Dausset, Jean

AU - Cohen, Daniel

AU - Cann, Howard

PY - 1994/9/30

Y1 - 1994/9/30

N2 - In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identity genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. It consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project - a comprehensive, high-density genetic map.

AB - In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identity genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. It consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project - a comprehensive, high-density genetic map.

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U2 - 10.1126/science.8091227

DO - 10.1126/science.8091227

M3 - Review article

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AN - SCOPUS:0027942568

SN - 0036-8075

VL - 265

SP - 2049

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JO - Science

JF - Science

IS - 5181

ER -

A comprehensive human linkage map with centimorgan density

Abstract

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