A comprehensive human linkage map with centimorgan density

Jeffrey C. Murray, Kenneth H. Buetow, James L. Weber, Susan Ludwigsen, Titia Scherpbier-Heddema, Frank Manion, John Quillen, Val C. Sheffield, Sara Sunden, Geoffrey M. Duyk, Jean Weissenbach, Gabor Gyapay, Colette Dib, Jean Morrissette, G. Mark Lathrop, Alain Vignal, Ray White, Norisada Matsunami, Steven Gerken, Roberta MelisHans Albertsen, Rosemarie Plaetke, Shannon Odelberg, David Ward, Jean Dausset, Daniel Cohen, Howard Cann

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Abstract

In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identity genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. It consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project - a comprehensive, high-density genetic map.

Original languageEnglish (US)
Pages (from-to)2049-2054
Number of pages6
JournalScience
Volume265
Issue number5181
DOIs
StatePublished - Sep 30 1994

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Cite this

Murray, J. C., Buetow, K. H., Weber, J. L., Ludwigsen, S., Scherpbier-Heddema, T., Manion, F., Quillen, J., Sheffield, V. C., Sunden, S., Duyk, G. M., Weissenbach, J., Gyapay, G., Dib, C., Morrissette, J., Lathrop, G. M., Vignal, A., White, R., Matsunami, N., Gerken, S., ... Cann, H. (1994). A comprehensive human linkage map with centimorgan density. Science, 265(5181), 2049-2054. https://doi.org/10.1126/science.8091227