Project Details

Description

AZ ASU Alzheimer's Reserach Center Project- Year 11 AZ ASU Alzheimer's Reserach Center Project- Year 11 A number of strategies to treat Alzheimers disease are being pursued including drug and immunotherapy. Any preventative treatment will probably require a diagnostic assay to accompany it. An ideal diagnostic would be one that could be easily and frequently administered, readily detect onset early and was able to discriminate Alzheimers from other neurological disorders. We have been developing a new platform technology immunosignaturing that may offer some progress toward the ideal diagnostic. The basic idea is that an array of 10,000 random sequence peptides can be used to signature the complexity of the immunoglobulins. We have demonstrated in the infectious disease framework that such arrays are very sensitive to changes in health state. The question we will explore in this grant will be whether this same protocol can be used to detect Alzheimers onset. There will be two classes of experiments conducted. Using mouse models of Alzheimers disease we will assay the blood of transgenic AZ mice and their normal littermates to determine if and how early the transgenic mice can be distinguished from the normal mice. This type of experiment will tell us if the distinction is at least feasible and help work out the technical details of the assay. The mouse models are not perfect models of the human disease. Therefore, in parallel we will also analyze human serum. This will include historical samples from Alzheimers patients and age matched controls, as well as serum from people with ApoE4 mutations that have a higher likelihood of contracting the disease. Since the immunoglobulins are quite stable, where possible we will use historical samples. Once a baseline has been established for the approach we will organize prospective studies.
StatusFinished
Effective start/end date7/1/086/30/09

Funding

  • Arizona Alzheimer's Consortium: $156,275.00

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