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Research Output 1986 2019

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2015
89 Citations (Scopus)

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

Fenalti, G., Zatsepin, N., Betti, C., Giguere, P., Han, G. W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., Spence, J., Boutet, S., Messerschmidt, M., Williams, G. J., Gati, C., Yefanov, O. M., White, T. A., Oberthuer, D. & 16 others, Metz, M., Yoon, C. H., Barty, A., Chapman, H. N., Basu, S., Coe, J., Conrad, C. E., Fromme, R., Fromme, P., Tourwé, D., Schiller, P. W., Roth, B. L., Ballet, S., Katritch, V., Stevens, R. C. & Cherezov, V., Mar 6 2015, In : Nature Structural and Molecular Biology. 22, 3, p. 265-268 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Peptides
Analgesics
Opiate Alkaloids
phenylalanylphenylalanine
20 Citations (Scopus)

Ternary structure reveals mechanism of a membrane diacylglycerol kinase

Li, D., Stansfeld, P. J., Sansom, M. S. P., Keogh, A., Vogeley, L., Howe, N., Lyons, J. A., Aragao, D., Fromme, P., Fromme, R., Basu, S., Grotjohann, I., Kupitz, C., Rendek, K., Weierstall, U., Zatsepin, N., Cherezov, V., Liu, W., Bandaru, S., English, N. J. & 10 others, Gati, C., Barty, A., Yefanov, O., Chapman, H. N., Diederichs, K., Messerschmidt, M., Boutet, S., Williams, G. J., Seibert, M. M. & Caffrey, M., Dec 17 2015, In : Nature Communications. 6, 10140.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
adenosine triphosphate
Adenosine Triphosphate
membranes
Membranes
15 Citations (Scopus)

XFELs open a new era in structural chemical biology

Fromme, P., Dec 1 2015, In : Nature Chemical Biology. 11, 12, p. 895-899 5 p.

Research output: Contribution to journalArticle

Molecular Models
Molecular Structure
Lasers
X-Rays
Proteins
2014
9 Citations (Scopus)

Draft genome sequence of the filamentous cyanobacterium Leptolyngbya sp. strain Heron Island J, exhibiting chromatic acclimation

Paul, R., Jinkerson, R. E., Buss, K., Steel, J., Mohr, R., Hess, W. R., Chen, M. & Fromme, P., 2014, In : Genome Announcements. 2, 1, e01166-13.

Research output: Contribution to journalArticle

Acclimatization
Cyanobacteria
Islands
Color
Axenic Culture
5 Citations (Scopus)

Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

Lee, H. H., Cherni, I., Yu, H., Fromme, R., Doran, J. D., Grotjohann, I., Mittman, M., Basu, S., Deb, A., Dörner, K., Aquila, A., Barty, A., Boutet, S., Chapman, H. N., Doak, R. B., Hunter, M. S., James, D., Kirian, R., Kupitz, C., Lawrence, R. M. & 17 others, Liu, H., Nass, K., Schlichting, I., Schmidt, K., Seibert, M. M., Shoeman, R. L., Spence, J., Stellato, F., Weierstall, U., Williams, G. J., Yoon, C., Wang, D., Zatsepin, N., Hogue, B., Matoba, N., Fromme, P. & Leket-Mor, T., Aug 29 2014, In : IUCrJ. 1, p. 305-317 13 p.

Research output: Contribution to journalArticle

vaccines
human immunodeficiency virus
Vaccines
Crystallization
Viruses
4 Citations (Scopus)

Leading-edge lasers

Fromme, P., 2014, In : Nature. 505, 7485, p. 620-621 2 p.

Research output: Contribution to journalArticle

276 Citations (Scopus)

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

Weierstall, U., James, D., Wang, C., White, T. A., Wang, D., Liu, W., Spence, J., Bruce Doak, R., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N., Liu, H., Basu, S., Wacker, D., Won Han, G., Katritch, V., Boutet, S. & 17 others, Messerschmidt, M., Williams, G. J., Koglin, J. E., Marvin Seibert, M., Klinker, M., Gati, C., Shoeman, R. L., Barty, A., Chapman, H. N., Kirian, R., Beyerlein, K. R., Stevens, R. C., Li, D., Shah, S. T. A., Howe, N., Caffrey, M. & Cherezov, V., Feb 14 2014, In : Nature Communications. 5, 3309.

Research output: Contribution to journalArticle

Crystallography
injectors
crystallography
Membrane Proteins
membranes
20 Citations (Scopus)

Low temperature assembly of functional 3D DNA-PNA-protein complexes

Flory, J. D., Simmons, C. R., Lin, S., Johnson, T., Andreoni, A., Zook, J., Ghirlanda, G., Liu, Y., Yan, H. & Fromme, P., Jun 11 2014, In : Journal of the American Chemical Society. 136, 23, p. 8283-8295 13 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
DNA
Proteins
Temperature
Azurin
36 Citations (Scopus)

Microcrystallization techniques for serial femtosecond crystallography using photosystem II from Thermosynechococcus elongatus as a model system

Kupitz, C., Grotjohann, I., Conrad, C. E., Roy-Chowdhury, S., Fromme, R. & Fromme, P., Jul 17 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1647, 20130316.

Research output: Contribution to journalArticle

Thermosynechococcus elongatus
crystallography
Crystallography
Microcrystals
Photosystem II Protein Complex
8 Citations (Scopus)

Probing the nature of charge transfer at nano-bio interfaces: Peptides on metal oxide nanoparticles

Pilarisetty, T., Palma, J. L., Holland, G. P., Fromme, P., Yarger, J. & Mujica, V., Oct 16 2014, In : Journal of Physical Chemistry Letters. 5, 20, p. 3555-3559 5 p.

Research output: Contribution to journalArticle

Oxides
Peptides
peptides
metal oxides
Photosystem I Protein Complex
2 Citations (Scopus)

Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage

Flory, J. D., Johnson, T., Simmons, C. R., Lin, S., Ghirlanda, G. & Fromme, P., 2014, In : Artificial DNA, PNA & XNA. 5, 3, p. 1-8 8 p.

Research output: Contribution to journalArticle

Purification
DNA
Coloring Agents
Electrophoresis
Peptides

Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage

Flory, J. D., Johnson, T., Simmons, C. D., Lin, S., Ghirlanda, G. & Fromme, P., Dec 15 2014, In : Artificial DNA, PNA & XNA. 5, 3, p. e992181

Research output: Contribution to journalArticle

Purification
DNA
Coloring Agents
Electrophoresis
Peptides
6 Citations (Scopus)

Purification and biophysical characterization of the CapA membrane protein FTT0807 from francisella tularensis

Martin-Garcia, J. M., Hansen, D., Zook, J., Loskutov, A. V., Robida, M. D., Craciunescu, F. M., Sykes, K. F., Wachter, R., Fromme, P. & Allen, J., Apr 1 2014, In : Biochemistry. 53, 12, p. 1958-1970 13 p.

Research output: Contribution to journalArticle

Francisella tularensis
Purification
Membrane Proteins
Green Fluorescent Proteins
Ionic strength
3 Citations (Scopus)

Recombinant expression, purification, and biophysical characterization of the transmembrane and membrane proximal domains of HIV-1 gp41

Gong, Z., Kessans, S. A., Song, L., Dörner, K., Lee, H. H., Meador, L. R., LaBaer, J., Hogue, B., Leket-Mor, T. & Fromme, P., Nov 1 2014, In : Protein Science. 23, 11, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

Purification
HIV-1
Membranes
Neutralizing Antibodies
Glycoproteins
258 Citations (Scopus)

Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser

Kupitz, C., Basu, S., Grotjohann, I., Fromme, R., Zatsepin, N., Rendek, K. N., Hunter, M. S., Shoeman, R. L., White, T. A., Wang, D., James, D., Yang, J. H., Cobb, D. E., Reeder, B., Sierra, R. G., Liu, H., Barty, A., Aquila, A. L., Deponte, D., Kirian, R. & 39 others, Bari, S., Bergkamp, J. J., Beyerlein, K. R., Bogan, M. J., Caleman, C., Chao, T. C., Conrad, C. E., Davis, K. M., Fleckenstein, H., Galli, L., Hau-Riege, S. P., Kassemeyer, S., Laksmono, H., Liang, M., Lomb, L., Marchesini, S., Martin, A. V., Messerschmidt, M., Milathianaki, D., Nass, K., Ros, A., Roy-Chowdhury, S., Schmidt, K., Seibert, M., Steinbrener, J., Stellato, F., Yan, L., Yoon, C., Moore, T., Moore, A., Pushkar, Y., Williams, G. J., Boutet, S., Doak, R. B., Weierstall, U., Frank, M., Chapman, H. N., Spence, J. & Fromme, P., Sep 11 2014, In : Nature. 513, 7517, p. 261-265 5 p.

Research output: Contribution to journalArticle

Crystallography
Photosystem II Protein Complex
Lasers
X-Rays
Photosynthesis
164 Citations (Scopus)

Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography

Zhang, H., Unal, H., Gati, C., Han, G. W., Liu, W., Zatsepin, N., James, D., Wang, D., Nelson, G., Weierstall, U., Sawaya, M. R., Xu, Q., Messerschmidt, M., Williams, G. J., Boutet, S., Yefanov, O. M., White, T. A., Wang, C., Ishchenko, A., Tirupula, K. C. & 8 others, Desnoyer, R., Coe, J., Conrad, C. E., Fromme, P., Stevens, R. C., Katritch, V., Karnik, S. S. & Cherezov, V., Nov 6 2014, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Crystallography
Angiotensin Receptors
Antihypertensive Agents
Angiotensin II Type 1 Receptor Blockers
208 Citations (Scopus)

Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein

Tenboer, J., Basu, S., Zatsepin, N., Pande, K., Milathianaki, D., Frank, M., Hunter, M., Boutet, S., Williams, G. J., Koglin, J. E., Oberthuer, D., Heymann, M., Kupitz, C., Conrad, C., Coe, J., Roy-Chowdhury, S., Weierstall, U., James, D., Wang, D., Grant, T. & 16 others, Barty, A., Yefanov, O., Scales, J., Gati, C., Seuring, C., Srajer, V., Henning, R., Schwander, P., Fromme, R., Ourmazd, A., Moffat, K., Van Thor, J. J., Spence, J., Fromme, P., Chapman, H. N. & Schmidt, M., Dec 5 2014, In : Science. 346, 6214, p. 1242-1246 5 p.

Research output: Contribution to journalArticle

Crystallography
Electrons
Light
Bacterial Proteins
Proteins
103 Citations (Scopus)

Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

Arnlund, D., Johansson, L. C., Wickstrand, C., Barty, A., Williams, G. J., Malmerberg, E., Davidsson, J., Milathianaki, D., DePonte, D. P., Shoeman, R. L., Wang, D., James, D., Katona, G., Westenhoff, S., White, T. A., Aquila, A., Bari, S., Berntsen, P., Bogan, M., Van Driel, T. B. & 26 others, Doak, R. B., Kjær, K. S., Frank, M., Fromme, R., Grotjohann, I., Henning, R., Hunter, M. S., Kirian, R., Kosheleva, I., Kupitz, C., Liang, M., Martin, A. V., Nielsen, M. M., Messerschmidt, M., Seibert, M. M., Sjöhamn, J., Stellato, F., Weierstall, U., Zatsepin, N., Spence, J., Fromme, P., Schlichting, I., Boutet, S., Groenhof, G., Chapman, H. N. & Neutze, R., 2014, In : Nature Methods. 11, 9, p. 923-926 4 p.

Research output: Contribution to journalArticle

Free electron lasers
X ray scattering
Lasers
X-Rays
Electrons
7 Citations (Scopus)

X-ray crystal structure of the passenger domain of plasmid encoded toxin(Pet), an autotransporter enterotoxin from enteroaggregative Escherichia coli (EAEC)

Domingo Meza-Aguilar, J., Fromme, P., Torres-Larios, A., Mendoza-Hernández, G., Hernandez-Chiñas, U., Arreguin-Espinosa De Los Monteros, R. A., Eslava Campos, C. A. & Fromme, R., Mar 7 2014, In : Biochemical and Biophysical Research Communications. 445, 2, p. 439-444 6 p.

Research output: Contribution to journalArticle

Enterotoxins
Escherichia coli
Plasmids
Crystal structure
X-Rays
2013
49 Citations (Scopus)

Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

Pieper, U., Schlessinger, A., Kloppmann, E., Chang, G. A., Chou, J. J., Dumont, M. E., Fox, B. G., Fromme, P., Hendrickson, W. A., Malkowski, M. G., Rees, D. C., Stokes, D. L., Stowell, M. H. B., Wiener, M. C., Rost, B., Stroud, R. M., Stevens, R. C. & Sali, A., Feb 2013, In : Nature Structural and Molecular Biology. 20, 2, p. 135-138 4 p.

Research output: Contribution to journalArticle

Proteome
Genomics
Membrane Proteins
Membranes
3 Citations (Scopus)

Crystallization of a self-assembled three-dimensional DNA nanostructure

Rendek, K. N., Fromme, R., Grotjohann, I. & Fromme, P., Feb 2013, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 2, p. 141-146 6 p.

Research output: Contribution to journalArticle

Nanostructures
Crystallization
tetrahedrons
deoxyribonucleic acid
crystallization
13 Citations (Scopus)

Crystallization of the large membrane protein complex photosystem i in a microfluidic channel

Abdallah, B. G., Kupitz, C., Fromme, P. & Ros, A., Dec 23 2013, In : ACS Nano. 7, 12, p. 10534-10543 10 p.

Research output: Contribution to journalArticle

Crystallization
Microfluidics
Membrane Proteins
crystallization
membranes
32 Citations (Scopus)

Dielectrophoretic sorting of membrane protein nanocrystals

Abdallah, B. G., Chao, T. C., Kupitz, C., Fromme, P. & Ros, A., Oct 22 2013, In : ACS Nano. 7, 10, p. 9129-9137 9 p.

Research output: Contribution to journalArticle

classifying
Sorting
Nanocrystals
nanocrystals
Membrane Proteins

High-resolution NMR reveals secondary structure and folding of amino acid transporter from outer chloroplast membrane.

Zook, J. D., Molugu, T. R., Jacobsen, N. E., Lin, G., Soll, J., Cherry, B., Brown, M. F. & Fromme, P., 2013, In : PLoS One. 8, 10, e78116.

Research output: Contribution to journalArticle

amino acid transporters
Amino Acid Transport Systems
Chloroplasts
chloroplasts
Nuclear magnetic resonance
293 Citations (Scopus)

Natively inhibited trypanosoma brucei cathepsin B structure determined by using an x-ray laser

Redecke, L., Nass, K., DePonte, D. P., White, T. A., Rehders, D., Barty, A., Stellato, F., Liang, M., Barends, T. R. M., Boutet, S., Williams, G. J., Messerschmidt, M., Seibert, M. M., Aquila, A., Arnlund, D., Bajt, S., Barth, T. B., Bogan, M. J., Caleman, C., Chao, T. C. & 29 others, Doak, R. B., Fleckenstein, H., Frank, M., Fromme, R., Galli, L., Grotjohann, I., Hunter, M. S., Johansson, L. C., Kassemeyer, S., Katona, G., Kirian, R., Koopmann, R., Kupitz, C., Lomb, L., Martin, A. V., Mogk, S., Neutze, R., Shoeman, R. L., Steinbrener, J., Timneanu, N., Wang, D., Weierstall, U., Zatsepin, N., Spence, J., Fromme, P., Schlichting, I., Duszenko, M., Betzel, C. & Chapman, H. N., Jan 11 2013, In : Science. 339, 6116, p. 227-230 4 p.

Research output: Contribution to journalArticle

Cathepsin B
Trypanosoma brucei brucei
Cysteine Proteases
Lasers
X-Rays
24 Citations (Scopus)

PNA-peptide assembly in a 3D DNA nanocage at room temperature

Flory, J. D., Shinde, S., Lin, S., Liu, Y., Yan, H., Ghirlanda, G. & Fromme, P., May 8 2013, In : Journal of the American Chemical Society. 135, 18, p. 6985-6993 9 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
Peptides
DNA
Temperature
Polypeptides
271 Citations (Scopus)

Serial femtosecond crystallography of G protein-coupled receptors

Liu, W., Wacker, D., Gati, C., Han, G. W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., Zatsepin, N., Li, D., Messerschmidt, M., Boutet, S., Williams, G. J., Koglin, J. E., Seibert, M. M., Wang, C., Shah, S. T. A., Basu, S. & 13 others, Fromme, R., Kupitz, C., Rendek, K. N., Grotjohann, I., Fromme, P., Kirian, R., Beyerlein, K. R., White, T. A., Chapman, H. N., Caffrey, M., Spence, J., Stevens, R. C. & Cherezov, V., 2013, In : Science. 342, 6165, p. 1521-1524 4 p.

Research output: Contribution to journalArticle

Protein
Laser
Damage
Temperature
Radiation
61 Citations (Scopus)

Structure of a photosynthetic reaction centre determined by serial femtosecond crystallography

Johansson, L. C., Arnlund, D., Katona, G., White, T. A., Barty, A., Deponte, D. P., Shoeman, R. L., Wickstrand, C., Sharma, A., Williams, G. J., Aquila, A., Bogan, M. J., Caleman, C., Davidsson, J., Doak, R. B., Frank, M., Fromme, R., Galli, L., Grotjohann, I., Hunter, M. S. & 25 others, Kassemeyer, S., Kirian, R., Kupitz, C., Liang, M., Lomb, L., Malmerberg, E., Martin, A. V., Messerschmidt, M., Nass, K., Redecke, L., Seibert, M. M., Sjöhamn, J., Steinbrener, J., Stellato, F., Wang, D., Wahlgren, W. Y., Weierstall, U., Westenhoff, S., Zatsepin, N., Boutet, S., Spence, J., Schlichting, I., Chapman, H. N., Fromme, P. & Neutze, R., Dec 19 2013, In : Nature Communications. 4, 2911.

Research output: Contribution to journalArticle

Photosynthetic Reaction Center Complex Proteins
Crystallography
Microcrystals
X Ray Crystallography
X-Ray Diffraction
2012
18 Citations (Scopus)

Alteration of proteins and pigments influence the function of photosystem i under iron deficiency from chlamydomonas reinhardtii

Yadavalli, V., Jolley, C. C., Malleda, C., Thangaraj, B., Fromme, P. & Subramanyam, R., Apr 13 2012, In : PLoS One. 7, 4, e35084.

Research output: Contribution to journalArticle

Chlamydomonas reinhardtii
Chlorophyll
Pigments
Iron
pigments
491 Citations (Scopus)

High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

Boutet, S., Lomb, L., Williams, G. J., Barends, T. R. M., Aquila, A., Doak, R. B., Weierstall, U., DePonte, D. P., Steinbrener, J., Shoeman, R. L., Messerschmidt, M., Barty, A., White, T. A., Kassemeyer, S., Kirian, R., Seibert, M. M., Montanez, P. A., Kenney, C., Herbst, R., Hart, P. & 34 others, Pines, J., Haller, G., Gruner, S. M., Philipp, H. T., Tate, M. W., Hromalik, M., Koerner, L. J., Van Bakel, N., Morse, J., Ghonsalves, W., Arnlund, D., Bogan, M. J., Caleman, C., Fromme, R., Hampton, C. Y., Hunter, M. S., Johansson, L. C., Katona, G., Kupitz, C., Liang, M., Martin, A. V., Nass, K., Redecke, L., Stellato, F., Timneanu, N., Wang, D., Zatsepin, N., Schafer, D., Defever, J., Neutze, R., Fromme, P., Spence, J., Chapman, H. N. & Schlichting, I., Jul 20 2012, In : Science. 337, 6092, p. 362-364 3 p.

Research output: Contribution to journalArticle

Crystallography
X-Rays
Synchrotrons
Muramidase
Proteins
29 Citations (Scopus)

Improving the accuracy of macromolecular structure refinement at 7 Å resolution

Brunger, A. T., Adams, P. D., Fromme, P., Fromme, R., Levitt, M. & Schröder, G. F., Jun 6 2012, In : Structure. 20, 6, p. 957-966 10 p.

Research output: Contribution to journalArticle

Photosystem I Protein Complex
Synchrotrons
X Ray Crystallography
Electrons
117 Citations (Scopus)

In vivo protein crystallization opens new routes in structural biology

Koopmann, R., Cupelli, K., Redecke, L., Nass, K., Deponte, D. P., White, T. A., Stellato, F., Rehders, D., Liang, M., Andreasson, J., Aquila, A., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C., Boutet, S., Bozek, J. D., Caleman, C., Coppola, N. & 49 others, Davidsson, J., Doak, R. B., Ekeberg, T., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, A., Hartmann, R., Hauser, G., Hirsemann, H., Holl, P., Hunter, M. S., Kassemeyer, S., Kirian, R., Lomb, L., Maia, F. R. N. C., Kimmel, N., Martin, A. V., Messerschmidt, M., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Schlichting, I., Schulz, J., Seibert, M. M., Shoeman, R. L., Sierra, R. G., Soltau, H., Stern, S., Strülder, L., Timneanu, N., Ullrich, J., Wang, X., Weidenspointner, G., Weierstall, U., Williams, G. J., Wunderer, C. B., Fromme, P., Spence, J., Stehle, T., Chapman, H. N., Betzel, C. & Duszenko, M., Mar 2012, In : Nature Methods. 9, 3, p. 259-262 4 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Crystallography
Systems Biology
Crystallization
Lasers
117 Citations (Scopus)

Lipidic phase membrane protein serial femtosecond crystallography

Johansson, L. C., Arnlund, D., White, T. A., Katona, G., Deponte, D. P., Weierstall, U., Doak, R. B., Shoeman, R. L., Lomb, L., Malmerberg, E., Davidsson, J., Nass, K., Liang, M., Andreasson, J., Aquila, A., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C. & 48 others, Bozek, J. D., Caleman, C., Coffee, R., Coppola, N., Ekeberg, T., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, R., Hartmann, A., Hauser, G., Hirsemann, H., Holl, P., Hunter, M. S., Kassemeyer, S., Kimmel, N., Kirian, R., Maia, F. R. N. C., Marchesini, S., Martin, A. V., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Schlichting, I., Schulz, J., Seibert, M. M., Sierra, R. G., Soltau, H., Starodub, D., Stellato, F., Stern, S., Strülder, L., Timneanu, N., Ullrich, J., Wahlgren, W. Y., Wang, X., Weidenspointner, G., Wunderer, C., Fromme, P., Chapman, H. N., Spence, J. & Neutze, R., Mar 2012, In : Nature Methods. 9, 3, p. 263-265 3 p.

Research output: Contribution to journalArticle

X ray lasers
Crystallography
Free electron lasers
Porifera
Membrane Proteins
230 Citations (Scopus)

Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements

Barty, A., Caleman, C., Aquila, A., Timneanu, N., Lomb, L., White, T. A., Andreasson, J., Arnlund, D., Bajt, S., Barends, T. R. M., Barthelmess, M., Bogan, M. J., Bostedt, C., Bozek, J. D., Coffee, R., Coppola, N., Davidsson, J., Deponte, D. P., Doak, R. B., Ekeberg, T. & 48 others, Elser, V., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Fromme, P., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, R., Hartmann, A., Hauser, G., Hirsemann, H., Holl, P., Hunter, M. S., Johansson, L., Kassemeyer, S., Kimmel, N., Kirian, R., Liang, M., Maia, F. R. N. C., Malmerberg, E., Marchesini, S., Martin, A. V., Nass, K., Neutze, R., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Scott, H., Schlichting, I., Schulz, J., Marvin Seibert, M., Shoeman, R. L., Sierra, R. G., Soltau, H., Spence, J., Stellato, F., Stern, S., Strüder, L., Ullrich, J., Wang, X., Weidenspointner, G., Weierstall, U., Wunderer, C. B. & Chapman, H. N., Jan 2012, In : Nature Photonics. 6, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

X ray lasers
Free electron lasers
stopping
Diffraction
Crystalline materials
142 Citations (Scopus)

Time-resolved protein nanocrystallography using an X-ray free-electron laser

Aquila, A., Hunter, M. S., Doak, R. B., Kirian, R., Fromme, P., White, T. A., Andreasson, J., Arnlund, D., Bajt, S., Barends, T. R. M., Barthelmess, M., Bogan, M. J., Bostedt, C., Bottin, H., Bozek, J. D., Caleman, C., Coppola, N., Davidsson, J., Deponte, D. P., Elser, V. & 59 others, Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Frank, M., Fromme, R., Graafsma, H., Grotjohann, I., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, A., Hartmann, R., Hau-Riege, S., Hauser, G., Hirsemann, H., Holl, P., Holton, J. M., Hömke, A., Johansson, L., Kimmel, N., Kassemeyer, S., Krasniqi, F., Kühnel, K. U., Liang, M., Lomb, L., Malmerberg, E., Marchesini, S., Martin, A. V., Maia, F. R. N. C., Messerschmidt, M., Nass, K., Reich, C., Neutze, R., Rolles, D., Rudek, B., Rudenko, A., Schlichting, I., Schmidt, C., Schmidt, K., Schulz, J., Marvin Seibert, M., Shoeman, R. L., Sierra, R., Soltau, H., Starodub, D., Stellato, F., Stern, S., Strüder, L., Timneanu, N., Ullrich, J., Wang, X., Williams, G. J., Weidenspointner, G., Weierstall, U., Wunderer, C., Barty, A., Spence, J. & Chapman, H. N., Jan 30 2012, In : Optics Express. 20, 3, p. 2706-2716 11 p.

Research output: Contribution to journalArticle

free electron lasers
proteins
electron transfer
crystals
x rays
2011
33 Citations (Scopus)

A novel photosynthetic strategy for adaptation to low-iron aquatic environments

Chauhan, D., Folea, I. M., Jolley, C. C., Kour̂il, R., Lubner, C. E., Lin, S., Kolber, D., Wolfe-Simon, F., Golbeck, J. H., Boekema, E. J. & Fromme, P., Feb 8 2011, In : Biochemistry. 50, 5, p. 686-692 7 p.

Research output: Contribution to journalArticle

Cyanobacteria
Iron
Photosynthetic membranes
Flavodoxin
Oxidative stress
18 Citations (Scopus)

Efficient light harvesting in a dark, hot, acidic environment: The structure and function of PSI-LHCI from Galdieria sulphuraria

Thangaraj, B., Jolley, C. C., Sarrou, I., Bultema, J. B., Greyslak, J., Whitelegge, J. P., Lin, S., Kouřil, R., Subramanyam, R., Boekema, E. J. & Fromme, P., Jan 5 2011, In : Biophysical Journal. 100, 1, p. 135-143 9 p.

Research output: Contribution to journalArticle

Photosystem I Protein Complex
Light
Spectrum Analysis
Rhodophyta
Plant Structures
54 Citations (Scopus)
X Ray Crystallography
Membrane Proteins
Lasers
X-Rays
Crystallography
1170 Citations (Scopus)

Femtosecond X-ray protein nanocrystallography

Chapman, H. N., Fromme, P., Barty, A., White, T. A., Kirian, R., Aquila, A., Hunter, M. S., Schulz, J., Deponte, D. P., Weierstall, U., Doak, R. B., Maia, F. R. N. C., Martin, A. V., Schlichting, I., Lomb, L., Coppola, N., Shoeman, R. L., Epp, S. W., Hartmann, R., Rolles, D. & 68 others, Rudenko, A., Foucar, L., Kimmel, N., Weidenspointner, G., Holl, P., Liang, M., Barthelmess, M., Caleman, C., Boutet, S., Bogan, M. J., Krzywinski, J., Bostedt, C., Bajt, S., Gumprecht, L., Rudek, B., Erk, B., Schmidt, C., Hömke, A., Reich, C., Pietschner, D., Ströder, L., Hauser, G., Gorke, H., Ullrich, J., Herrmann, S., Schaller, G., Schopper, F., Soltau, H., Kühnel, K. U., Messerschmidt, M., Bozek, J. D., Hau-Riege, S. P., Frank, M., Hampton, C. Y., Sierra, R. G., Starodub, D., Williams, G. J., Hajdu, J., Timneanu, N., Seibert, M. M., Andreasson, J., Rocker, A., Jönsson, O., Svenda, M., Stern, S., Nass, K., Andritschke, R., Schröter, C. D., Krasniqi, F., Bott, M., Schmidt, K., Wang, X., Grotjohann, I., Holton, J. M., Barends, T. R. M., Neutze, R., Marchesini, S., Fromme, R., Schorb, S., Rupp, D., Adolph, M., Gorkhover, T., Andersson, I., Hirsemann, H., Potdevin, G., Graafsma, H., Nilsson, B. & Spence, J., Feb 3 2011, In : Nature. 470, 7332, p. 73-78 6 p.

Research output: Contribution to journalArticle

Nanoparticles
Photosystem I Protein Complex
X-Rays
Radiation
Membrane Proteins
7 Citations (Scopus)

Isolation, folding and structural investigations of the amino acid transporter OEP16

Ni, D. Q., Zook, J., Klewer, D. A., Nieman, R. A., Soll, J. & Fromme, P., Dec 2011, In : Protein Expression and Purification. 80, 2, p. 157-168 12 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Membrane Proteins
Micelles
Detergents
Proteins
113 Citations (Scopus)

Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser

Lomb, L., Barends, T. R. M., Kassemeyer, S., Aquila, A., Epp, S. W., Erk, B., Foucar, L., Hartmann, R., Rudek, B., Rolles, D., Rudenko, A., Shoeman, R. L., Andreasson, J., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C., Bozek, J. D., Caleman, C. & 45 others, Coffee, R., Coppola, N., Deponte, D. P., Doak, R. B., Ekeberg, T., Fleckenstein, H., Fromme, P., Gebhardt, M., Graafsma, H., Gumprecht, L., Hampton, C. Y., Hartmann, A., Hauser, G., Hirsemann, H., Holl, P., Holton, J. M., Hunter, M. S., Kabsch, W., Kimmel, N., Kirian, R., Liang, M., Maia, F. R. N. C., Meinhart, A., Marchesini, S., Martin, A. V., Nass, K., Reich, C., Schulz, J., Seibert, M. M., Sierra, R., Soltau, H., Spence, J., Steinbrener, J., Stellato, F., Stern, S., Timneanu, N., Wang, X., Weidenspointner, G., Weierstall, U., White, T. A., Wunderer, C., Chapman, H. N., Ullrich, J., Strüder, L. & Schlichting, I., Dec 20 2011, In : Physical Review B - Condensed Matter and Materials Physics. 84, 21, 214111.

Research output: Contribution to journalArticle

x ray lasers
Crystallography
Free electron lasers
Radiation damage
radiation damage
3 Citations (Scopus)

Recombinant production and purification of the subunit c of chloroplast ATP synthase

Lawrence, R. M., Varco-Merth, B., Bley, C. J., Chen, J. & Fromme, P., Mar 2011, In : Protein Expression and Purification. 76, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

Chloroplasts
Adenosine Triphosphate
Maltose-Binding Proteins
Spinacia oleracea
Protons
594 Citations (Scopus)

Single mimivirus particles intercepted and imaged with an X-ray laser

Seibert, M. M., Ekeberg, T., Maia, F. R. N. C., Svenda, M., Andreasson, J., Jönsson, O., Odić, D., Iwan, B., Rocker, A., Westphal, D., Hantke, M., Deponte, D. P., Barty, A., Schulz, J., Gumprecht, L., Coppola, N., Aquila, A., Liang, M., White, T. A., Martin, A. & 69 others, Caleman, C., Stern, S., Abergel, C., Seltzer, V., Claverie, J. M., Bostedt, C., Bozek, J. D., Boutet, S., Miahnahri, A. A., Messerschmidt, M., Krzywinski, J., Williams, G., Hodgson, K. O., Bogan, M. J., Hampton, C. Y., Sierra, R. G., Starodub, D., Andersson, I., Bajt, S., Barthelmess, M., Spence, J., Fromme, P., Weierstall, U., Kirian, R., Hunter, M., Doak, R. B., Marchesini, S., Hau-Riege, S. P., Frank, M., Shoeman, R. L., Lomb, L., Epp, S. W., Hartmann, R., Rolles, D., Rudenko, A., Schmidt, C., Foucar, L., Kimmel, N., Holl, P., Rudek, B., Erk, B., Hömke, A., Reich, C., Pietschner, D., Weidenspointner, G., Strüder, L., Hauser, G., Gorke, H., Ullrich, J., Schlichting, I., Herrmann, S., Schaller, G., Schopper, F., Soltau, H., Kühnel, K. U., Andritschke, R., Schröter, C. D., Krasniqi, F., Bott, M., Schorb, S., Rupp, D., Adolph, M., Gorkhover, T., Hirsemann, H., Potdevin, G., Graafsma, H., Nilsson, B., Chapman, H. N. & Hajdu, J., Feb 3 2011, In : Nature. 470, 7332, p. 78-82 5 p.

Research output: Contribution to journalArticle

Mimiviridae
Lasers
X-Rays
Viruses
Photons
105 Citations (Scopus)

Structure-factor analysis of femtosecond microdiffraction patterns from protein nanocrystals

Kirian, R., White, T. A., Holton, J. M., Chapman, H. N., Fromme, P., Barty, A., Lomb, L., Aquila, A., Maia, F. R. N. C., Martin, A. V., Fromme, R., Wang, X., Hunter, M. S., Schmidt, K. & Spence, J., Mar 2011, In : Acta Crystallographica Section A: Foundations of Crystallography. 67, 2, p. 131-140 10 p.

Research output: Contribution to journalArticle

factor analysis
Factor analysis
Nanoparticles
Nanocrystals
Statistical Factor Analysis
42 Citations (Scopus)

Toward structure determination using membrane-protein nanocrystals and microcrystals

Hunter, M. S. & Fromme, P., Dec 2011, In : Methods. 55, 4, p. 387-404 18 p.

Research output: Contribution to journalArticle

Microcrystals
Nanoparticles
Nanocrystals
Membrane Proteins
Photosystem I Protein Complex
44 Citations (Scopus)

X-ray diffraction from Membrane protein nanocrystals

Hunter, M. S., DePonte, D. P., Shapiro, D. A., Kirian, R., Wang, X., Starodub, D., Marchesini, S., Weierstall, U., Doak, R. B., Spence, J. & Fromme, P., Jan 5 2011, In : Biophysical Journal. 100, 1, p. 198-206 9 p.

Research output: Contribution to journalArticle

X-Ray Diffraction
Nanoparticles
Membrane Proteins
X-Rays
Electrons
2010
29 Citations (Scopus)

Data-directed top-down Fourier-transform mass spectrometry of a large integral membrane protein complex: Photosystem II from Galdieria sulphuraria

Thangaraj, B., Ryan, C. M., Souda, P., Krause, K., Faull, K. F., Weber, A. P. M., Fromme, P. & Whitelegge, J. P., Oct 2010, In : Proteomics. 10, 20, p. 3644-3656 13 p.

Research output: Contribution to journalArticle

Photosystem II Protein Complex
Fourier Analysis
Methionine
Mass spectrometry
Mass Spectrometry
154 Citations (Scopus)

Femtosecond protein nanocrystallography- Data analysis methods

Kirian, R., Wang, X., Weierstall, U., Schmidt, K., Spence, J., Hunter, M., Fromme, P., White, T., Chapman, H. N. & Holton, J., Mar 15 2010, In : Optics Express. 18, 6, p. 5713-5723 11 p.

Research output: Contribution to journalArticle

nanocrystals
proteins
shot
pulses
radiation damage
14 Citations (Scopus)

Structural and functional changes of PSI-LHCI supercomplexes of Chlamydomonas reinhardtii cells grown under high salt conditions

Subramanyam, R., Jolley, C., Thangaraj, B., Nellaepalli, S., Webber, A. & Fromme, P., Mar 2010, In : Planta. 231, 4, p. 913-922 10 p.

Research output: Contribution to journalArticle

Photosystem I Protein Complex
Chlamydomonas reinhardtii
light harvesting complex
photosystem I
Salts
2009
1 Citation (Scopus)

Chapter 6 Membrane Protein Crystallization: Approaching the Problem and Understanding the Solutions

Gabrielsen, M., Gardiner, A. T., Fromme, P. & Cogdell, R. J., 2009, In : Current Topics in Membranes. 63, p. 127-149 23 p.

Research output: Contribution to journalArticle

Crystallization
Membrane Proteins