Joseph Blattman

Associate Professor

  • 6567 Citations
  • 28 h-Index
19982020
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Research Output 1998 2019

  • 6567 Citations
  • 28 h-Index
  • 44 Article
  • 1 Comment/debate
  • 1 Review article
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Article
2019
Open Access
Ownership
Students
Research
experience
student
2017
1 Citation (Scopus)

A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles

Meador, L. R., Kessans, S. A., Kilbourne, J., Kibler, K., Pantaleo, G., Roderiguez, M. E., Blattman, J., Jacobs, B. & Leket-Mor, T., Jul 1 2017, In : Virology. 507, p. 242-256 15 p.

Research output: Contribution to journalArticle

Vaccinia virus
Virion
HIV-1
Epitopes
T-Lymphocytes
6 Citations (Scopus)
Boidae
Python
dehydration (animal physiology)
Dehydration
Hydration

Sequence-specific detection of different strains of LCMV in a single sample using tentacle probes

Franco, L. S., Holechek, S. A., Caplan, M. & Blattman, J., Oct 13 2017, In : Virology Journal. 14, 1, 197.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
Clone Cells
Viruses
Complementary DNA
Costs and Cost Analysis
2016
27 Citations (Scopus)

Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

Lussier, D. M., Woolf, E. C., Johnson, J. L., Brooks, K. S., Blattman, J. & Scheck, A. C., 2016, In : BMC Cancer. 16, 1, 310.

Research output: Contribution to journalArticle

Ketogenic Diet
Glioma
Immunity
Neoplasms
T-Lymphocytes

Retinaldehyde dehydrogenase 2 as a molecular adjuvant for enhancement of mucosal immunity during DNA vaccination

Holechek, S. A., McAfee, M. S., Nieves, L. M., Guzman, V. P., Manhas, K., Fouts, T., Bagley, K. & Blattman, J., Nov 4 2016, In : Vaccine. 34, 46, p. 5629-5635 7 p.

Research output: Contribution to journalArticle

retinaldehyde
Retinaldehyde
mucosal immunity
Mucosal Immunity
retinoic acid
2015
76 Citations (Scopus)
Osteosarcoma
Immunotherapy
Antibodies
Neoplasms
Lung Diseases
70 Citations (Scopus)

Enhanced T-cell immunity to osteosarcoma through antibody blockade of PD-1/PD-L1 interactions

Lussier, D. M., O'Neill, L., Nieves, L. M., McAfee, M. S., Holechek, S. A., Collins, A. W., Dickman, P., Jacobsen, J., Hingorani, P. & Blattman, J., Mar 27 2015, In : Journal of Immunotherapy. 38, 3, p. 96-106 11 p.

Research output: Contribution to journalArticle

Osteosarcoma
Immunity
Cytotoxic T-Lymphocytes
T-Lymphocytes
Antibodies
2 Citations (Scopus)

Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity

McAfee, M. S., Huynh, T. P., Johnson, J. L., Jacobs, B. & Blattman, J., Oct 1 2015, In : Virology. 484, p. 153-162 10 p.

Research output: Contribution to journalArticle

Ectromelia virus
Lymphocytic choriomeningitis virus
Coinfection
Virus Diseases
Immunity
53 Citations (Scopus)

TCR contact residue hydrophobicity is a hallmark of immunogenic CD8<sup>+</sup> T cell epitopes

Chowell, D., Krishna, S., Becker, P. D., Cocita, C., Shu, J., Tan, X., Greenberg, P. D., Klavinskis, L. S., Blattman, J. & Anderson, K., Apr 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 14, p. E1754-E1762

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Hydrophobic and Hydrophilic Interactions
Epitopes
Major Histocompatibility Complex
Peptides
2014
5 Citations (Scopus)

Nuclear factor kappa b is required for the production of infectious human herpesvirus 8 virions

Blattman, N. N., Lagunoff, M., Blattman, J. & Corey, L., 2014, In : Frontiers in Microbiology. 5, APR, Article 129.

Research output: Contribution to journalArticle

Human Herpesvirus 8
NF-kappa B
Virion
Foreskin
Fibroblasts
2013
17 Citations (Scopus)

Engineering recombinant reoviruses with tandem repeats and a tetravirus 2A-like element for exogenous polypeptide expression

Demidenko, A. A., Blattman, J., Blattman, N. N., Greenberg, P. D. & Nibert, M. L., May 14 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 20

Research output: Contribution to journalArticle

Tandem Repeat Sequences
Genome
Peptides
RNA
gag Gene Products
56 Citations (Scopus)

Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire

Zarnitsyna, V. I., Evavold, B. D., Schoettle, L. N., Blattman, J. & Antia, R., 2013, In : Frontiers in Immunology. 4, DEC, Article 485.

Research output: Contribution to journalArticle

T-Lymphocytes
T-Cell Antigen Receptor
Immune System
Clone Cells
Epitopes
2012
31 Citations (Scopus)

Abrogation of Src homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo

Stromnes, I. M., Fowler, C., Casamina, C. C., Georgopolos, C. M., McAfee, M. S., Schmitt, T. M., Tan, X., Kim, T. D., Choi, I., Blattman, J. & Greenberg, P. D., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1812-1825 14 p.

Research output: Contribution to journalArticle

SH2 Domain-Containing Protein Tyrosine Phosphatases
Adoptive Immunotherapy
src Homology Domains
T-Lymphocytes
Neoplasms
2 Citations (Scopus)

Combating chronic T-cell exhaustion

McAfee, M. S. & Blattman, J., Jun 2012, In : Immunotherapy. 4, 6, p. 557-560 4 p.

Research output: Contribution to journalArticle

Immune Evasion
Immune Tolerance
Gene Expression Profiling
Immunotherapy
Chronic Disease
99 Citations (Scopus)

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

Wegmann, F., Gartlan, K. H., Harandi, A. M., Brinckmann, S. A., Coccia, M., Hillson, W. R., Kok, W. L., Cole, S., Ho, L. P., Lambe, T., Puthia, M., Svanborg, C., Scherer, E. M., Krashias, G., Williams, A., Blattman, J., Greenberg, P. D., Flavell, R. A., Moghaddam, A. E., Sheppard, N. C. & 1 others, Sattentau, Q. J., Sep 2012, In : Nature Biotechnology. 30, 9, p. 883-888 6 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Glycoproteins
Viral Antigens
Antigens
Nucleic acids
100 Citations (Scopus)

Rescued tolerant CD8 T cells are preprogrammed to reestablish the tolerant state

Schietinger, A., Delrow, J. J., Basom, R. S., Blattman, J. & Greenberg, P. D., Feb 10 2012, In : Science. 335, 6069, p. 723-727 5 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Autoantigens
Self Tolerance
Antigens
MicroRNAs
2011
45 Citations (Scopus)

Multiple innate immune pathways contribute to the immunogenicity of recombinant adenovirus vaccine vectors

Rhee, E. G., Blattman, J., Kasturi, S. P., Kelley, R. P., Kaufman, D. R., Lynch, D. M., La Porte, A., Simmons, N. L., Clark, S. L., Pulendran, B., Greenberg, P. D. & Barouch, D. H., Jan 2011, In : Journal of Virology. 85, 1, p. 315-323 9 p.

Research output: Contribution to journalArticle

Adenovirus Vaccines
vector vaccines
Synthetic Vaccines
Adenoviridae
Toll-Like Receptors
43 Citations (Scopus)

Retinoic acid as a vaccine adjuvant enhances CD8 + T cell response and mucosal protection from viral challenge

Tan, X., Sande, J. L., Pufnock, J. S., Blattman, J. & Greenberg, P. D., Aug 2011, In : Journal of Virology. 85, 16, p. 8316-8327 12 p.

Research output: Contribution to journalArticle

vaccine adjuvants
retinoic acid
Tretinoin
Vaccines
T-lymphocytes
22 Citations (Scopus)

Vaccination alters the balance between protective immunity, exhaustion, escape, and death in chronic infections

Johnson, P. L. F., Kochin, B. F., McAfee, M. S., Stromnes, I. M., Regoes, R. R., Ahmed, R., Blattman, J. & Antia, R., Jun 2011, In : Journal of Virology. 85, 11, p. 5565-5570 6 p.

Research output: Contribution to journalArticle

Immunity
Vaccination
T-lymphocytes
immunity
vaccination
2010
48 Citations (Scopus)

Abrogating Cbl-b in effector CD8+ T cells improves the efficacy of adoptive therapy of leukemia in mice

Stromnes, I. M., Blattman, J., Tan, X., Jeevanjee, S., Gu, H. & Greenberg, P. D., Oct 1 2010, In : Journal of Clinical Investigation. 120, 10, p. 3722-3734 13 p.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
T-Lymphocytes
Interleukin-2
Adoptive Immunotherapy
28 Citations (Scopus)

SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells

Fowler, C. C., Pao, L. I., Blattman, J. & Greenberg, P. D., Sep 15 2010, In : Journal of Immunology. 185, 6, p. 3256-3267 12 p.

Research output: Contribution to journalArticle

T-Lymphocytes
SH2 Domain-Containing Protein Tyrosine Phosphatases
src Homology Domains
Long-Term Memory
Virus Diseases
2009
98 Citations (Scopus)

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection

Blattman, J., Wherry, E. J., Ha, S. J., Van Der Most, R. G. & Ahmed, R., May 2009, In : Journal of Virology. 83, 9, p. 4386-4394 9 p.

Research output: Contribution to journalArticle

epitopes
Epitopes
T-lymphocytes
T-Lymphocytes
Infection

P02-05. All-trans retinoic acid during vaccination increases Ag-specific CD8 T cell homing to mucosal sites and improves recall responses to vaginal challenge

Blattman, J., Tan, X., Sande, J., Pufnock, J. & Greenberg, P., Sep 22 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalArticle

Tretinoin
Vaccination
T-Lymphocytes
2007
947 Citations (Scopus)

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S. J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J., Barber, D. L. & Ahmed, R., Oct 26 2007, In : Immunity. 27, 4, p. 670-684 15 p.

Research output: Contribution to journalArticle

Virus Diseases
T-Lymphocytes
Lymphocytic choriomeningitis virus
Programmed Cell Death 1 Receptor
Infection
2 Citations (Scopus)

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection (DOI: 10.1016/j.immuni.2007.09.006)

Wherry, E. J., Ha, S. J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J., Barber, D. L. & Ahmed, R., Nov 26 2007, In : Immunity. 27, 5, p. 824 1 p.

Research output: Contribution to journalArticle

Virus Diseases
T-Lymphocytes
160 Citations (Scopus)

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

Shin, H., Blackburn, S. D., Blattman, J. & Wherry, E. J., Apr 16 2007, In : Journal of Experimental Medicine. 204, 4, p. 941-949 9 p.

Research output: Contribution to journalArticle

Viral Antigens
Viruses
T-Lymphocytes
Infection
Interleukin-15
2006
23 Citations (Scopus)

PD-1 blockade: Rescue from a near-death experience

Blattman, J. & Greenberg, P. D., Mar 2006, In : Nature Immunology. 7, 3, p. 227-228 2 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Virus Diseases
2005
87 Citations (Scopus)

Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination

Wherry, E. J., Blattman, J. & Ahmed, R., Jul 2005, In : Journal of Virology. 79, 14, p. 8960-8968 9 p.

Research output: Contribution to journalArticle

viral load
Viral Load
Vaccination
T-lymphocytes
vaccination
2004
357 Citations (Scopus)

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

Wherry, E. J., Barber, D. L., Kaech, S. M., Blattman, J. & Ahmed, R., Nov 9 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 45, p. 16004-16009 6 p.

Research output: Contribution to journalArticle

Virus Diseases
T-Lymphocytes
Antigens
Interleukin-7
Infection
446 Citations (Scopus)

Cancer immunotherapy: A treatment for the masses

Blattman, J. & Greenberg, P. D., Jul 9 2004, In : Science. 305, 5681, p. 200-205 6 p.

Research output: Contribution to journalArticle

Immunotherapy
Neoplasms
Immune System
Therapeutics
Allergy and Immunology
175 Citations (Scopus)

Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5

Zhang, Y., Blattman, J., Kennedy, N. J., Duong, J., Hguyen, T., Wang, Y., Davis, R. J., Greenberg, P. D., Flavell, R. A. & Dong, C., Aug 12 2004, In : Nature. 430, 7001, p. 793-797 5 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Phosphatases
Adaptive Immunity
Innate Immunity
Mitogen-Activated Protein Kinases
T-Lymphocytes
2003
114 Citations (Scopus)

Adoptive immunotherapy: Engineering T cell responses as biologic weapons for tumor mass destruction

Ho, W. Y., Blattman, J., Dossett, M. L., Yee, C. & Greenberg, P. D., May 2003, In : Cancer Cell. 3, 5, p. 431-437 7 p.

Research output: Contribution to journalArticle

Weapons of Mass Destruction
Adoptive Immunotherapy
Immunotherapy
Technology
T-Lymphocytes
80 Citations (Scopus)

Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation

Van Der Most, R. G., Murali-Krishna, K., Lanier, J. G., Wherry, E. J., Puglielli, M. T., Blattman, J., Sette, A. & Ahmed, R., Oct 10 2003, In : Virology. 315, 1, p. 93-102 10 p.

Research output: Contribution to journalArticle

Antiviral Agents
Epitopes
T-Lymphocytes
Nucleoproteins
Infection
45 Citations (Scopus)

Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent

Seiffert, M., Custodio, J. M., Wolf, I., Harkey, M., Liu, Y., Blattman, J., Greenberg, P. D. & Rohrschneider, L. R., Apr 2003, In : Molecular and Cellular Biology. 23, 7, p. 2415-2424 10 p.

Research output: Contribution to journalArticle

Hematopoiesis
Macrophages
Macrophage Colony-Stimulating Factor Receptors
Antigen Receptors
Cytokine Receptors
33 Citations (Scopus)

Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy

Slifka, M. K., Blattman, J., Sourdive, D. J. D., Liu, F., Huffman, D. L., Wolfe, T., Hughes, A., Oldstone, M. B. A., Ahmed, R. & Von Herrath, M. G., Feb 1 2003, In : Journal of Immunology. 170, 3, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

Antiviral Agents
T-Lymphocytes
Epitopes
Complementarity Determining Regions
Virus Diseases
115 Citations (Scopus)

Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production

Topp, M. S., Riddell, S. R., Akatsuka, Y., Jensen, M. C., Blattman, J. & Greenberg, P. D., Sep 15 2003, In : Journal of Experimental Medicine. 198, 6, p. 947-955 9 p.

Research output: Contribution to journalArticle

Interleukin-2
T-Lymphocytes
Antigens
Aptitude
Virus Diseases
268 Citations (Scopus)

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

Blattman, J., Grayson, J. M., Wherry, E. J., Kaech, S. M., Smith, K. A. & Ahmed, R., May 1 2003, In : Nature Medicine. 9, 5, p. 540-547 8 p.

Research output: Contribution to journalArticle

T-cells
Therapeutic Uses
Interleukin-2
Antiviral Agents
T-Lymphocytes
924 Citations (Scopus)

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

Wherry, E. J., Blattman, J., Murali-Krishna, K., Van Der Most, R. & Ahmed, R., Apr 2003, In : Journal of Virology. 77, 8, p. 4911-4927 17 p.

Research output: Contribution to journalArticle

tissue distribution
Tissue Distribution
T-lymphocytes
T-Lymphocytes
Lymphocytic choriomeningitis virus
2002
23 Citations (Scopus)

CD8+ T cell responses: It's all downhill after their prime..

Blattman, J., Cheng, L. E. & Greenberg, P. D., 2002, In : Nature Immunology. 3, 7, p. 601-602 2 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigens
Infection
424 Citations (Scopus)

Estimating the precursor frequency of naive antigen-specific CD8 T cells

Blattman, J., Antia, R., Sourdive, D. J. D., Wang, X., Kaech, S. M., Murali-Krishna, K., Altman, J. D. & Ahmed, R., Mar 4 2002, In : Journal of Experimental Medicine. 195, 5, p. 657-664 8 p.

Research output: Contribution to journalArticle

CD8 Antigens
T-Lymphocytes
Lymphocytic choriomeningitis virus
Antigens
Epitopes
2000
129 Citations (Scopus)

Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection

Blattman, J., Sourdive, D. J. D., Murali-Krishna, K., Ahmed, R. & Altman, J. D., Dec 1 2000, In : Journal of Immunology. 165, 11, p. 6081-6090 10 p.

Research output: Contribution to journalArticle

Virus Diseases
T-Lymphocytes
Complementarity Determining Regions
Lymphocytic choriomeningitis virus
Epitopes
1998
102 Citations (Scopus)

Therapeutic vaccination against chronic viral infection: The importance of cooperation between CD4+ and CD8+ T cells

Zajac, A. J., Murali-Krishna, K., Blattman, J. & Ahmed, R., Aug 1998, In : Current Opinion in Immunology. 10, 4, p. 444-449 6 p.

Research output: Contribution to journalArticle

Virus Diseases
Vaccination
T-Lymphocytes
Antiviral Agents
Therapeutics
1275 Citations (Scopus)

Viral immune evasion due to persistence of activated T cells without effector function

Zajac, A. J., Blattman, J., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D. & Ahmed, R., 1998, In : Journal of Experimental Medicine. 188, 12, p. 2205-2213 9 p.

Research output: Contribution to journalArticle

Immune Evasion
T-Lymphocytes
Antiviral Agents
Virus Diseases
Viruses