TY - JOUR
T1 - Wearable Transcutaneous CO Monitor Based on Miniaturized Nondispersive Infrared Sensor
AU - Tipparaju, Vishal Varun
AU - Mora, Sabrina Jimena
AU - Yu, Jingjing
AU - Tsow, Francis
AU - Xian, Xiaojun
N1 - Funding Information:
Manuscript received April 1, 2021; revised May 9, 2021; accepted May 12, 2021. Date of publication May 19, 2021; date of current version July 30, 2021. This work was supported by National Institutes of Health (NIH) (Project Number: 5R44HL123164-04). The associate editor coordinating the review of this article and approving it for publication was Dr. Sanket Goel. (Corresponding author: Xiaojun Xian.) This work involved human subjects or animals in its research. Approval of all ethical and experimental procedures and protocols was granted by Institutional Review Board of Arizona State University under Approval No. STUDY00013474.
Publisher Copyright:
© 2001-2012 IEEE.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Transcutaneous oxygen and carbon dioxide provide the status of pulmonary gas exchange and are of importance in diagnosis and management of respiratory diseases. Though significant progress has been made in oximetry, not much has been explored in developing wearable technologies for continuous monitoring of transcutaneous carbon dioxide. This research reports the development of a truly wearable sensor for continuous monitoring of transcutaneous carbon dioxide using miniaturized nondispersive infrared sensor augmented by hydrophobic membrane to address the humidity interference. The wearable transcutaneous CO2 monitor shows well-behaved response curve to humid CO2 with linear response to CO2 concentration. The profile of transcutaneous CO2 monitored by the wearable device correlates well with the end-tidal CO2 trend in human test. The feasibility of the wearable device for passive and unobstructed tracking of transcutaneous CO2 in free-living conditions has also been demonstrated in field test. The wearable transcutaneous CO2 monitoring technology developed in this research can be widely used in remote assessment of pulmonary gas exchange efficiency for patients with respiratory diseases, such as COVID-19, sleep apnea, and chronic obstructive pulmonary disease (COPD).
AB - Transcutaneous oxygen and carbon dioxide provide the status of pulmonary gas exchange and are of importance in diagnosis and management of respiratory diseases. Though significant progress has been made in oximetry, not much has been explored in developing wearable technologies for continuous monitoring of transcutaneous carbon dioxide. This research reports the development of a truly wearable sensor for continuous monitoring of transcutaneous carbon dioxide using miniaturized nondispersive infrared sensor augmented by hydrophobic membrane to address the humidity interference. The wearable transcutaneous CO2 monitor shows well-behaved response curve to humid CO2 with linear response to CO2 concentration. The profile of transcutaneous CO2 monitored by the wearable device correlates well with the end-tidal CO2 trend in human test. The feasibility of the wearable device for passive and unobstructed tracking of transcutaneous CO2 in free-living conditions has also been demonstrated in field test. The wearable transcutaneous CO2 monitoring technology developed in this research can be widely used in remote assessment of pulmonary gas exchange efficiency for patients with respiratory diseases, such as COVID-19, sleep apnea, and chronic obstructive pulmonary disease (COPD).
KW - Arterial blood gases
KW - end-tidal CO2
KW - nondispersive infrared (NDIR) sensor
KW - respiratory diseases
KW - transcutaneous CO2
KW - wearable
KW - wristband
UR - http://www.scopus.com/inward/record.url?scp=85107204518&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107204518&partnerID=8YFLogxK
U2 - 10.1109/JSEN.2021.3081696
DO - 10.1109/JSEN.2021.3081696
M3 - Article
AN - SCOPUS:85107204518
SN - 1530-437X
VL - 21
SP - 17327
EP - 17334
JO - IEEE Sensors Journal
JF - IEEE Sensors Journal
IS - 15
M1 - 9435386
ER -